Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study
Abstract Background The association between impaired lung function and mortality has been well documented in the general population of Western European countries. We assessed the risk of death associated with reduced spirometry indices among people from four Central and Eastern European countries. M...
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BMC
2022-05-01
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| Series: | Respiratory Research |
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| Online Access: | https://doi.org/10.1186/s12931-022-02057-y |
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| author | Tatyana Court Nadezda Capkova Andrzej Pająk Sofia Malyutina Galina Simonova Abdonas Tamosiunas Martin Bobák Hynek Pikhart |
| author_facet | Tatyana Court Nadezda Capkova Andrzej Pająk Sofia Malyutina Galina Simonova Abdonas Tamosiunas Martin Bobák Hynek Pikhart |
| author_sort | Tatyana Court |
| collection | DOAJ |
| description | Abstract Background The association between impaired lung function and mortality has been well documented in the general population of Western European countries. We assessed the risk of death associated with reduced spirometry indices among people from four Central and Eastern European countries. Methods This prospective population-based cohort includes men and women aged 45–69 years, residents in urban settlements in Czech Republic, Poland, Russia and Lithuania, randomly selected from population registers. The baseline survey in 2002–2005 included 36,106 persons of whom 24,993 met the inclusion criteria. Cox proportional hazards models were used to estimate the hazard ratios of mortality over 11–16 years of follow-up for mild, moderate, moderate-severe and very severe lung function impairment categories. Results After adjusting for covariates, mild (hazard ratio (HR): 1.25; 95% CI 1.15‒1.37) to severe (HR: 3.35; 95% CI 2.62‒4.27) reduction in FEV1 was associated with an increased risk of death according to degree of lung impairment, compared to people with normal lung function. The association was only slightly attenuated but remained significant after exclusion of smokers and participants with previous history of respiratory diseases. The HRs varied between countries but not statistically significant; the highest excess risk among persons with more severe impairment was seen in Poland (HR: 4.28, 95% CI 2.14‒8.56) and Lithuania (HR: 4.07, 95% CI 2.21‒7.50). Conclusions Reduced FEV1 is an independent predictor of all-cause mortality, with risk increasing with the degree of lung function impairment and some country-specific variation between the cohorts. |
| format | Article |
| id | doaj-art-644620f1507b4c44aaa54e937bb45b09 |
| institution | OA Journals |
| issn | 1465-993X |
| language | English |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj-art-644620f1507b4c44aaa54e937bb45b092025-08-20T02:25:41ZengBMCRespiratory Research1465-993X2022-05-0123111010.1186/s12931-022-02057-yImpaired lung function and mortality in Eastern Europe: results from multi-centre cohort studyTatyana Court0Nadezda Capkova1Andrzej Pająk2Sofia Malyutina3Galina Simonova4Abdonas Tamosiunas5Martin Bobák6Hynek Pikhart7Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk UniversityNational Institute of Public HealthDepartment of Epidemiology and Population Sciences, Institute of Public Health, Jagiellonian University Medical CollegeResearch Institute of Internal and Preventive Medicine – Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesResearch Institute of Internal and Preventive Medicine – Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesLaboratory of Population Research, Institute of Cardiology, Lithuanian University of Health SciencesResearch Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk UniversityResearch Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk UniversityAbstract Background The association between impaired lung function and mortality has been well documented in the general population of Western European countries. We assessed the risk of death associated with reduced spirometry indices among people from four Central and Eastern European countries. Methods This prospective population-based cohort includes men and women aged 45–69 years, residents in urban settlements in Czech Republic, Poland, Russia and Lithuania, randomly selected from population registers. The baseline survey in 2002–2005 included 36,106 persons of whom 24,993 met the inclusion criteria. Cox proportional hazards models were used to estimate the hazard ratios of mortality over 11–16 years of follow-up for mild, moderate, moderate-severe and very severe lung function impairment categories. Results After adjusting for covariates, mild (hazard ratio (HR): 1.25; 95% CI 1.15‒1.37) to severe (HR: 3.35; 95% CI 2.62‒4.27) reduction in FEV1 was associated with an increased risk of death according to degree of lung impairment, compared to people with normal lung function. The association was only slightly attenuated but remained significant after exclusion of smokers and participants with previous history of respiratory diseases. The HRs varied between countries but not statistically significant; the highest excess risk among persons with more severe impairment was seen in Poland (HR: 4.28, 95% CI 2.14‒8.56) and Lithuania (HR: 4.07, 95% CI 2.21‒7.50). Conclusions Reduced FEV1 is an independent predictor of all-cause mortality, with risk increasing with the degree of lung function impairment and some country-specific variation between the cohorts.https://doi.org/10.1186/s12931-022-02057-yForced expiratory volume in one secondPulmonary function testCohort studyMortality |
| spellingShingle | Tatyana Court Nadezda Capkova Andrzej Pająk Sofia Malyutina Galina Simonova Abdonas Tamosiunas Martin Bobák Hynek Pikhart Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study Respiratory Research Forced expiratory volume in one second Pulmonary function test Cohort study Mortality |
| title | Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study |
| title_full | Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study |
| title_fullStr | Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study |
| title_full_unstemmed | Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study |
| title_short | Impaired lung function and mortality in Eastern Europe: results from multi-centre cohort study |
| title_sort | impaired lung function and mortality in eastern europe results from multi centre cohort study |
| topic | Forced expiratory volume in one second Pulmonary function test Cohort study Mortality |
| url | https://doi.org/10.1186/s12931-022-02057-y |
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