Spermidine reduces ISGylation and enhances ISG15–USP18 interaction
Abstract The expression of ubiquitin-like molecule interferon-stimulated gene 15 kDa (ISG15) and its post-translational modification (ISGylation) are significantly activated by interferons or pathogen infections, highlighting their roles in innate immune responses. Over 1100 proteins have been ident...
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| Main Authors: | Haruka Etori, Riko Asoshina, Takayuki Obita, Fumihiko Okumura |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-01425-0 |
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