Nicorandil Ameliorates Depression‐Like Behaviors After Traumatic Brain Injury by Suppressing Ferroptosis Through the SLC7A11/GPX4 Axis in the Hippocampus

Nicorandil Ameliorates Depression‐Like Behaviors After Traumatic Brain Injury by Suppressing Ferroptosis Through the SLC7A11/GPX4 Axis in the Hippocampus

ABSTRACT Introduction Depression is a prevalent and significant psychological consequence of traumatic brain injury (TBI). Ferroptosis, an iron‐dependent form of regulated cell death, exacerbates the neurological damage associated with TBI. This study investigates whether nicorandil, a potassium cha...

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Bibliographic Details
Main Authors: Yao‐Ran Tu, Ming Tan, Yao Li, De‐Quan Hong, Fan Niu
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Brain and Behavior
Subjects:
depression
ferroptosis
nicorandil
the SLC7A11/GPX4 axis
traumatic brain injury
Online Access:https://doi.org/10.1002/brb3.70199
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