Disability and progression in Afro-descendant patients with multiple sclerosis
ABSTRACT Multiple sclerosis (MS) prevalence is higher in Caucasian (CA) populations, narrowing the analysis of the impact of Afro-descendant (AD) populations in disease outcomes. Even so, recent studies observed that AD patients have a more severe course. The main objective of this study is to confi...
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| Language: | English |
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Thieme Revinter Publicações
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001000836&lng=en&tlng=en |
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| author | Juliana Calvet Kallenbach Aurenção Claudia Cristina Ferreira Vasconcelos Luiz Claudio Santos Thuler Regina Maria Papais Alvarenga |
| author_facet | Juliana Calvet Kallenbach Aurenção Claudia Cristina Ferreira Vasconcelos Luiz Claudio Santos Thuler Regina Maria Papais Alvarenga |
| author_sort | Juliana Calvet Kallenbach Aurenção |
| collection | DOAJ |
| description | ABSTRACT Multiple sclerosis (MS) prevalence is higher in Caucasian (CA) populations, narrowing the analysis of the impact of Afro-descendant (AD) populations in disease outcomes. Even so, recent studies observed that AD patients have a more severe course. The main objective of this study is to confirm and discuss, through a systematic review, that being AD is a risk factor for disability accumulation and/or severe progression in patients with MS. A systematic review of published data in the last eleven years was performed, which evaluated clinical aspects and long term disability in patients with MS. Fourteen studies were included. Of these fourteen articles, thirteen observed a relationship between ancestry and poorer outcome of MS. African ancestry is a condition inherent in the patient and should be considered as an initial clinical characteristic affecting prognosis, and influencing which therapeutic decision to make in initial phases. |
| format | Article |
| id | doaj-art-6432bd3d35604e18ac993bfad83eb7b8 |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-6432bd3d35604e18ac993bfad83eb7b82025-08-20T03:19:32ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-4227741083684110.1590/0004-282X20160118S0004-282X2016001000836Disability and progression in Afro-descendant patients with multiple sclerosisJuliana Calvet Kallenbach AurençãoClaudia Cristina Ferreira VasconcelosLuiz Claudio Santos ThulerRegina Maria Papais AlvarengaABSTRACT Multiple sclerosis (MS) prevalence is higher in Caucasian (CA) populations, narrowing the analysis of the impact of Afro-descendant (AD) populations in disease outcomes. Even so, recent studies observed that AD patients have a more severe course. The main objective of this study is to confirm and discuss, through a systematic review, that being AD is a risk factor for disability accumulation and/or severe progression in patients with MS. A systematic review of published data in the last eleven years was performed, which evaluated clinical aspects and long term disability in patients with MS. Fourteen studies were included. Of these fourteen articles, thirteen observed a relationship between ancestry and poorer outcome of MS. African ancestry is a condition inherent in the patient and should be considered as an initial clinical characteristic affecting prognosis, and influencing which therapeutic decision to make in initial phases.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001000836&lng=en&tlng=enmultiple sclerosisdisease progressiondisability, Afro-descent |
| spellingShingle | Juliana Calvet Kallenbach Aurenção Claudia Cristina Ferreira Vasconcelos Luiz Claudio Santos Thuler Regina Maria Papais Alvarenga Disability and progression in Afro-descendant patients with multiple sclerosis Arquivos de Neuro-Psiquiatria multiple sclerosis disease progression disability, Afro-descent |
| title | Disability and progression in Afro-descendant patients with multiple sclerosis |
| title_full | Disability and progression in Afro-descendant patients with multiple sclerosis |
| title_fullStr | Disability and progression in Afro-descendant patients with multiple sclerosis |
| title_full_unstemmed | Disability and progression in Afro-descendant patients with multiple sclerosis |
| title_short | Disability and progression in Afro-descendant patients with multiple sclerosis |
| title_sort | disability and progression in afro descendant patients with multiple sclerosis |
| topic | multiple sclerosis disease progression disability, Afro-descent |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2016001000836&lng=en&tlng=en |
| work_keys_str_mv | AT julianacalvetkallenbachaurencao disabilityandprogressioninafrodescendantpatientswithmultiplesclerosis AT claudiacristinaferreiravasconcelos disabilityandprogressioninafrodescendantpatientswithmultiplesclerosis AT luizclaudiosantosthuler disabilityandprogressioninafrodescendantpatientswithmultiplesclerosis AT reginamariapapaisalvarenga disabilityandprogressioninafrodescendantpatientswithmultiplesclerosis |