Coexistence of PMQR and ESBL genes among clinical Escherichia coli isolates from community-acquired UTI in Mexicali, on the US-Mexico border
Escherichia coli is an opportunistic pathogen and a leading cause of Community-Acquired Urinary Tract Infections (CA-UTIs). E. coli can harbor multiple genetic resistant determinants, such as Extended Spectrum Beta-lactamases (ESBL) and Plasmid-Mediated Quinolone Resistance (PMQR) genes, complicatin...
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Elsevier
2025-07-01
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| Series: | Brazilian Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1413867025000558 |
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| author | Dolores A. Marquez-Salazar Ricardo Delgadillo-Valles Gerson N. Hernandez-Acevedo Edwin Barrios-Villa Raquel Muñiz-Salazar Gilberto Lopez-Valencia Paulina Haro Enrique Trasviña-Muñoz Rafael Martinez-Miranda Jonathan Arauz-Cabrera |
| author_facet | Dolores A. Marquez-Salazar Ricardo Delgadillo-Valles Gerson N. Hernandez-Acevedo Edwin Barrios-Villa Raquel Muñiz-Salazar Gilberto Lopez-Valencia Paulina Haro Enrique Trasviña-Muñoz Rafael Martinez-Miranda Jonathan Arauz-Cabrera |
| author_sort | Dolores A. Marquez-Salazar |
| collection | DOAJ |
| description | Escherichia coli is an opportunistic pathogen and a leading cause of Community-Acquired Urinary Tract Infections (CA-UTIs). E. coli can harbor multiple genetic resistant determinants, such as Extended Spectrum Beta-lactamases (ESBL) and Plasmid-Mediated Quinolone Resistance (PMQR) genes, complicating the empirical treatment of UTIs with β-lactams and quinolones. The aim of his study was to characterize ESBL and PMQR genes among E. coli isolates from CA-UTI in Mexicali, Mexico Isolates were collected from January to December 2023. Identification was performed by MALDI-TOF, and ESBL-producing determination and antimicrobial susceptibility by Vitek 2. Detection of ESBL and PMQR, and phylotyping were performed by PCR. Genetic diversity was determined by Enterobacterial Repetitive Intergenic Consensus Polymerase Chain Reaction (ERIC-PCR). Eighty-nine E. coli isolates were collected from CA-UTIs. All exhibited resistance to ciprofloxacin, ceftriaxone, and cefotaxime, while being susceptible to carbapenems and ceftazidime/avibactam. All isolates tested positive for an ESBL gene, with blaCTX−M (98.9 %) being the most prevalent. Five isolates tested negative for PMQR genes; the remaining showed aac(6′)-lb-cr present in 85.3 %. Coexistence between ESBL and PMQR genes was noted in 95.5 %. Most prevalent plylogenetic group was group B2 (74.2 %). This study provides valuable regional data, highlighting a public health problem due to the high prevalence of ESBL and PMQR genes in E. coli responsible for CA-UTI, which are linked to multidrug resistance. Genetic diversity was found, suggesting multiple sources of resistant strains in the community. These findings underline the need for surveillance and control to limit the spread of resistant E. coli, locally and globally. Data summary: The authors confirm all supporting data, code, and protocols have been provided within the article or through supplementary data files. |
| format | Article |
| id | doaj-art-642a447fef3c45e1ada601cdf1aeb138 |
| institution | DOAJ |
| issn | 1413-8670 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj-art-642a447fef3c45e1ada601cdf1aeb1382025-08-20T02:42:34ZengElsevierBrazilian Journal of Infectious Diseases1413-86702025-07-0129410455410.1016/j.bjid.2025.104554Coexistence of PMQR and ESBL genes among clinical Escherichia coli isolates from community-acquired UTI in Mexicali, on the US-Mexico borderDolores A. Marquez-Salazar0Ricardo Delgadillo-Valles1Gerson N. Hernandez-Acevedo2Edwin Barrios-Villa3Raquel Muñiz-Salazar4Gilberto Lopez-Valencia5Paulina Haro6Enrique Trasviña-Muñoz7Rafael Martinez-Miranda8Jonathan Arauz-Cabrera9Universidad Autónoma de Baja California, Facultad de Medicina Mexicali, Departamento de Farmacología, Humberto Torres Sanginés SN, Centro Cívico, Mexicali, Baja California, MexicoUniversidad Autónoma de Baja California, Facultad de Medicina Mexicali, Departamento de Microbiología y Parasitología Clínica, Humberto Torres Sanginés SN, Centro Cívico, Mexicali, Baja California, MexicoUniversidad Autónoma de Baja California, Facultad de Medicina Mexicali, Departamento de Microbiología y Parasitología Clínica, Humberto Torres Sanginés SN, Centro Cívico, Mexicali, Baja California, MexicoUniversidad de Sonora, Campus Caborca, Departamento de Ciencias Químico Biológicas y Agropecuarias, Laboratorio de Biología Molecular y Genómica Sonora, MexicoUniversidad Autónoma de Baja California, Escuela de Ciencias de la Salud, Unidad Valle Dorado, Campus Ensenada, Laboratorio de Epidemiología y Ecología Molecular, Baja California, MexicoUniversidad Autónoma de Baja California, Instituto de Investigaciones en Ciencias Veterinarias, Baja California, MexicoUniversidad Autónoma de Baja California, Instituto de Investigaciones en Ciencias Veterinarias, Baja California, MexicoUniversidad Autónoma de Baja California, Instituto de Investigaciones en Ciencias Veterinarias, Baja California, MexicoHospital Almater, Departamento de Microbiología, Mexicali, Baja California, MexicoUniversidad Autónoma de Baja California, Facultad de Medicina Mexicali, Departamento de Farmacología, Humberto Torres Sanginés SN, Centro Cívico, Mexicali, Baja California, Mexico; Corresponding author.Escherichia coli is an opportunistic pathogen and a leading cause of Community-Acquired Urinary Tract Infections (CA-UTIs). E. coli can harbor multiple genetic resistant determinants, such as Extended Spectrum Beta-lactamases (ESBL) and Plasmid-Mediated Quinolone Resistance (PMQR) genes, complicating the empirical treatment of UTIs with β-lactams and quinolones. The aim of his study was to characterize ESBL and PMQR genes among E. coli isolates from CA-UTI in Mexicali, Mexico Isolates were collected from January to December 2023. Identification was performed by MALDI-TOF, and ESBL-producing determination and antimicrobial susceptibility by Vitek 2. Detection of ESBL and PMQR, and phylotyping were performed by PCR. Genetic diversity was determined by Enterobacterial Repetitive Intergenic Consensus Polymerase Chain Reaction (ERIC-PCR). Eighty-nine E. coli isolates were collected from CA-UTIs. All exhibited resistance to ciprofloxacin, ceftriaxone, and cefotaxime, while being susceptible to carbapenems and ceftazidime/avibactam. All isolates tested positive for an ESBL gene, with blaCTX−M (98.9 %) being the most prevalent. Five isolates tested negative for PMQR genes; the remaining showed aac(6′)-lb-cr present in 85.3 %. Coexistence between ESBL and PMQR genes was noted in 95.5 %. Most prevalent plylogenetic group was group B2 (74.2 %). This study provides valuable regional data, highlighting a public health problem due to the high prevalence of ESBL and PMQR genes in E. coli responsible for CA-UTI, which are linked to multidrug resistance. Genetic diversity was found, suggesting multiple sources of resistant strains in the community. These findings underline the need for surveillance and control to limit the spread of resistant E. coli, locally and globally. Data summary: The authors confirm all supporting data, code, and protocols have been provided within the article or through supplementary data files.http://www.sciencedirect.com/science/article/pii/S1413867025000558Escherichia coliResistotypeCommunity-acquired infectionESBLPMQR |
| spellingShingle | Dolores A. Marquez-Salazar Ricardo Delgadillo-Valles Gerson N. Hernandez-Acevedo Edwin Barrios-Villa Raquel Muñiz-Salazar Gilberto Lopez-Valencia Paulina Haro Enrique Trasviña-Muñoz Rafael Martinez-Miranda Jonathan Arauz-Cabrera Coexistence of PMQR and ESBL genes among clinical Escherichia coli isolates from community-acquired UTI in Mexicali, on the US-Mexico border Brazilian Journal of Infectious Diseases Escherichia coli Resistotype Community-acquired infection ESBL PMQR |
| title | Coexistence of PMQR and ESBL genes among clinical Escherichia coli isolates from community-acquired UTI in Mexicali, on the US-Mexico border |
| title_full | Coexistence of PMQR and ESBL genes among clinical Escherichia coli isolates from community-acquired UTI in Mexicali, on the US-Mexico border |
| title_fullStr | Coexistence of PMQR and ESBL genes among clinical Escherichia coli isolates from community-acquired UTI in Mexicali, on the US-Mexico border |
| title_full_unstemmed | Coexistence of PMQR and ESBL genes among clinical Escherichia coli isolates from community-acquired UTI in Mexicali, on the US-Mexico border |
| title_short | Coexistence of PMQR and ESBL genes among clinical Escherichia coli isolates from community-acquired UTI in Mexicali, on the US-Mexico border |
| title_sort | coexistence of pmqr and esbl genes among clinical escherichia coli isolates from community acquired uti in mexicali on the us mexico border |
| topic | Escherichia coli Resistotype Community-acquired infection ESBL PMQR |
| url | http://www.sciencedirect.com/science/article/pii/S1413867025000558 |
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