Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair

Abstract Nucleotide excision repair (NER) represents one of the major molecular machineries that control chromosome stability in all living species. In Eubacteria, the initial stages of the repair process are carried out by the UvrABC excinuclease complex. Despite the wealth of structural data avail...

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Main Authors: Marianna Genta, Giulia Ferrara, Riccardo Capelli, Diego Rondelli, Sarah Sertic, Martino Bolognesi, Menico Rizzi, Franca Rossi, David Jeruzalmi, Antonio Chaves-Sanjuan, Riccardo Miggiano
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58670-0
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