APOE gene polymorphism as a potential predictor of postoperative cognitive dysfunction in colon cancer surgery under general anesthesia
Background/Aim. Postoperative cognitive dysfunction (POCD) occurs very often in operated patients. This increasingly frequent complication compromises the recovery of operated patients, impairs the quality of life of patients and their families, prolongs the length of hospital stay, and inc...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2025-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0042-8450/2025/0042-84502500025B.pdf |
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| Summary: | Background/Aim. Postoperative cognitive dysfunction (POCD) occurs very often
in operated patients. This increasingly frequent complication compromises
the recovery of operated patients, impairs the quality of life of patients
and their families, prolongs the length of hospital stay, and increases the
cost of treatment. The aim of the study was to examine the association
between the apolipoprotein E (APOE) ε4 allele and sociodemographic and
clinical characteristics with the occurrence of POCD seven days and three
months after colon cancer surgery (CCS) under general anesthesia (GA).
Methods. A total of 113 patients aged 18 to 87 years who underwent CCS under
GA in the period from 2021 to 2023 participated in the study. Preoperative
preparation, anesthesia, and postoperative treatment were uniform and
standardized for all patients. The assessment of cognitive status was
conducted using the Mini Mental State Examination psychometric test on the
day before surgery, on the seventh postoperative day, and three months after
surgery. Results. Seven days after surgery, a statistically significant
impairment of cognitive functions was found in patients with the APOE ε4
allele in their genotype (p = 0.007). Patients 65 years old or above were
more likely to have POCD three months after surgery compared to younger
patients (80.0% vs. 52.9%; p = 0.003). Conclusion. The presence of the APOE
ε4 allele is a potential predictor of the occurrence of POCD seven days
after surgery, and age is a significant sociodemographic factor for the
occurrence of POCD three months after CCS is performed under GA. |
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| ISSN: | 0042-8450 2406-0720 |