Biodynamic Characteristics and Blood Pressure Effects of Stanford Type B Aortic Dissection Based on an Accurate Constitutive Model
Aortic dissection (AD) is a highly lethal cardiovascular emergency, and clinical studies have found that a high percentage of AD patients are hypertensive. In previous studies, the AD model was simplified, such as by treating the vessel wall as a single-layer rigid material, ignoring the complex bio...
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2025-05-01
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| author | Yiwen Wang Libo Xin Lijie Zhou Xuefeng Wu Jinong Zhang Zhaoqi Wang |
| author_facet | Yiwen Wang Libo Xin Lijie Zhou Xuefeng Wu Jinong Zhang Zhaoqi Wang |
| author_sort | Yiwen Wang |
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| description | Aortic dissection (AD) is a highly lethal cardiovascular emergency, and clinical studies have found that a high percentage of AD patients are hypertensive. In previous studies, the AD model was simplified, such as by treating the vessel wall as a single-layer rigid material, ignoring the complex biomechanical factors of the vascular lumen. This study elucidates key biomechanical mechanisms by which hypertension promotes primary AD progression using multiscale modeling. First, based on experimental data from longitudinal and circumferential uniaxial tensile testing of porcine aortic walls (5–7-month-old specimens), a constitutive model of the aortic wall was developed using the Holzapfel–Gasser–Ogden (HGO) framework. The material parameters were calibrated via inverse optimization in ABAQUS-ISIGHT, achieving close alignment with mechanical properties of the human aorta. Using this validated model to define the hyperelastic properties of the aortic wall, a multiphysics coupling platform was constructed in COMSOL Multiphysics 6.2, integrating computational fluid dynamics (CFD) and fluid–structure interaction (FSI) algorithms. This framework systematically quantified the effects of blood pressure (bp) fluctuations on compressive stresses, von Mises stresses, and deformation of the intimal flap within the AD lesion region. With constant blood rheology, elevated blood pressure enhances wall stresses (compressive and von Mises), and intima-media sheet deformation, this can trigger initial rupture tears, false lumen dilation, and branch arterial flow obstruction, ultimately deteriorating end-organ perfusion. |
| format | Article |
| id | doaj-art-64255f964ffb480ea419a3d10240135e |
| institution | DOAJ |
| issn | 2076-3417 |
| language | English |
| publishDate | 2025-05-01 |
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| spelling | doaj-art-64255f964ffb480ea419a3d10240135e2025-08-20T03:11:30ZengMDPI AGApplied Sciences2076-34172025-05-011511585310.3390/app15115853Biodynamic Characteristics and Blood Pressure Effects of Stanford Type B Aortic Dissection Based on an Accurate Constitutive ModelYiwen Wang0Libo Xin1Lijie Zhou2Xuefeng Wu3Jinong Zhang4Zhaoqi Wang5School of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbi 150080, ChinaSchool of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbi 150080, ChinaSchool of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbi 150080, ChinaSchool of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbi 150080, ChinaSchool of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbi 150080, ChinaSchool of Mechanical and Power Engineering, Harbin University of Science and Technology, Harbi 150080, ChinaAortic dissection (AD) is a highly lethal cardiovascular emergency, and clinical studies have found that a high percentage of AD patients are hypertensive. In previous studies, the AD model was simplified, such as by treating the vessel wall as a single-layer rigid material, ignoring the complex biomechanical factors of the vascular lumen. This study elucidates key biomechanical mechanisms by which hypertension promotes primary AD progression using multiscale modeling. First, based on experimental data from longitudinal and circumferential uniaxial tensile testing of porcine aortic walls (5–7-month-old specimens), a constitutive model of the aortic wall was developed using the Holzapfel–Gasser–Ogden (HGO) framework. The material parameters were calibrated via inverse optimization in ABAQUS-ISIGHT, achieving close alignment with mechanical properties of the human aorta. Using this validated model to define the hyperelastic properties of the aortic wall, a multiphysics coupling platform was constructed in COMSOL Multiphysics 6.2, integrating computational fluid dynamics (CFD) and fluid–structure interaction (FSI) algorithms. This framework systematically quantified the effects of blood pressure (bp) fluctuations on compressive stresses, von Mises stresses, and deformation of the intimal flap within the AD lesion region. With constant blood rheology, elevated blood pressure enhances wall stresses (compressive and von Mises), and intima-media sheet deformation, this can trigger initial rupture tears, false lumen dilation, and branch arterial flow obstruction, ultimately deteriorating end-organ perfusion.https://www.mdpi.com/2076-3417/15/11/5853hypertensionStanford type B aortic dissectionHGO constitutive modelcomputational fluid dynamicsfluid–structure interaction |
| spellingShingle | Yiwen Wang Libo Xin Lijie Zhou Xuefeng Wu Jinong Zhang Zhaoqi Wang Biodynamic Characteristics and Blood Pressure Effects of Stanford Type B Aortic Dissection Based on an Accurate Constitutive Model Applied Sciences hypertension Stanford type B aortic dissection HGO constitutive model computational fluid dynamics fluid–structure interaction |
| title | Biodynamic Characteristics and Blood Pressure Effects of Stanford Type B Aortic Dissection Based on an Accurate Constitutive Model |
| title_full | Biodynamic Characteristics and Blood Pressure Effects of Stanford Type B Aortic Dissection Based on an Accurate Constitutive Model |
| title_fullStr | Biodynamic Characteristics and Blood Pressure Effects of Stanford Type B Aortic Dissection Based on an Accurate Constitutive Model |
| title_full_unstemmed | Biodynamic Characteristics and Blood Pressure Effects of Stanford Type B Aortic Dissection Based on an Accurate Constitutive Model |
| title_short | Biodynamic Characteristics and Blood Pressure Effects of Stanford Type B Aortic Dissection Based on an Accurate Constitutive Model |
| title_sort | biodynamic characteristics and blood pressure effects of stanford type b aortic dissection based on an accurate constitutive model |
| topic | hypertension Stanford type B aortic dissection HGO constitutive model computational fluid dynamics fluid–structure interaction |
| url | https://www.mdpi.com/2076-3417/15/11/5853 |
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