Combination of ICSs and LABAs Should Be Used in the Management of Patients with COPD -- The Pro Argument
THE EFFECTS OF INHALED CORTICOSTEROID MONOTHERAPY Airway inflammation is a prominent feature of chronic obstructive pulmonary disease (COPD), even among ex-smokers (1), and its intensity is directly related to the severity of the underlying COPD (2). The inflammatory burden increases during pe...
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Wiley
2004-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2004/178072 |
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| author | Don D Sin |
| author_facet | Don D Sin |
| author_sort | Don D Sin |
| collection | DOAJ |
| description | THE EFFECTS OF INHALED CORTICOSTEROID MONOTHERAPY Airway inflammation is a prominent feature of chronic obstructive pulmonary disease (COPD), even among ex-smokers (1), and its intensity is directly related to the severity of the underlying COPD (2). The inflammatory burden increases during periods of clinical exacerbation (3-5). Predictably, use of systemic corticosteroids during these episodes accelerates clinical recovery and improves health outcomes over several months of follow-up (6). Unfortunately, long term use of systemic corticosteroids is generally precluded by their toxic side effects. Inhaled corticosteroids, on the other hand, share much of the anti-inflammatory properties of the systemic formulations without the side effects (7). However, their effectiveness has been questioned and is a matter of heated debate among members of the scientific community (8,9). |
| format | Article |
| id | doaj-art-6424f5344c9442afb02149e71bb7ce82 |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-6424f5344c9442afb02149e71bb7ce822025-02-03T01:04:26ZengWileyCanadian Respiratory Journal1198-22412004-01-0111322122310.1155/2004/178072Combination of ICSs and LABAs Should Be Used in the Management of Patients with COPD -- The Pro ArgumentDon D Sin0James Hogg iCapture Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, British Columbia, CanadaTHE EFFECTS OF INHALED CORTICOSTEROID MONOTHERAPY Airway inflammation is a prominent feature of chronic obstructive pulmonary disease (COPD), even among ex-smokers (1), and its intensity is directly related to the severity of the underlying COPD (2). The inflammatory burden increases during periods of clinical exacerbation (3-5). Predictably, use of systemic corticosteroids during these episodes accelerates clinical recovery and improves health outcomes over several months of follow-up (6). Unfortunately, long term use of systemic corticosteroids is generally precluded by their toxic side effects. Inhaled corticosteroids, on the other hand, share much of the anti-inflammatory properties of the systemic formulations without the side effects (7). However, their effectiveness has been questioned and is a matter of heated debate among members of the scientific community (8,9).http://dx.doi.org/10.1155/2004/178072 |
| spellingShingle | Don D Sin Combination of ICSs and LABAs Should Be Used in the Management of Patients with COPD -- The Pro Argument Canadian Respiratory Journal |
| title | Combination of ICSs and LABAs Should Be Used in the Management of Patients with COPD -- The Pro Argument |
| title_full | Combination of ICSs and LABAs Should Be Used in the Management of Patients with COPD -- The Pro Argument |
| title_fullStr | Combination of ICSs and LABAs Should Be Used in the Management of Patients with COPD -- The Pro Argument |
| title_full_unstemmed | Combination of ICSs and LABAs Should Be Used in the Management of Patients with COPD -- The Pro Argument |
| title_short | Combination of ICSs and LABAs Should Be Used in the Management of Patients with COPD -- The Pro Argument |
| title_sort | combination of icss and labas should be used in the management of patients with copd the pro argument |
| url | http://dx.doi.org/10.1155/2004/178072 |
| work_keys_str_mv | AT dondsin combinationoficssandlabasshouldbeusedinthemanagementofpatientswithcopdtheproargument |