Cerebellar Involvement in an Immunocompetent Patient Presenting with Progressive Multifocal Leukoencephalopathy
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by the JC virus, a polyomavirus that can be reactivated under certain immunosuppressive conditions, such as AIDS, immunomodulatory therapy, and haematological malignancies. However, a few cases of immunocompetent pati...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/2396068 |
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| author | Rafael Garcia-Carretero Blanca San Jose Montano |
| author_facet | Rafael Garcia-Carretero Blanca San Jose Montano |
| author_sort | Rafael Garcia-Carretero |
| collection | DOAJ |
| description | Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by the JC virus, a polyomavirus that can be reactivated under certain immunosuppressive conditions, such as AIDS, immunomodulatory therapy, and haematological malignancies. However, a few cases of immunocompetent patients have been reported in which no immunodeficiency was present. We describe the case of an 83-year-old immunocompetent man who presented with severe cerebellar symptoms with an MRI scan suggestive of severe demyelinating disease. We were not able to identify any occult immunosuppression or malignancy in our patient. |
| format | Article |
| id | doaj-art-6424e998075c4d2b9b180b16892b41b5 |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-6424e998075c4d2b9b180b16892b41b52025-02-03T01:21:07ZengWileyCase Reports in Neurological Medicine2090-66682090-66762017-01-01201710.1155/2017/23960682396068Cerebellar Involvement in an Immunocompetent Patient Presenting with Progressive Multifocal LeukoencephalopathyRafael Garcia-Carretero0Blanca San Jose Montano1Department of Internal Medicine, Mostoles University Hospital, Madrid, SpainHealth Science Library, Mostoles University Hospital, Madrid, SpainProgressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by the JC virus, a polyomavirus that can be reactivated under certain immunosuppressive conditions, such as AIDS, immunomodulatory therapy, and haematological malignancies. However, a few cases of immunocompetent patients have been reported in which no immunodeficiency was present. We describe the case of an 83-year-old immunocompetent man who presented with severe cerebellar symptoms with an MRI scan suggestive of severe demyelinating disease. We were not able to identify any occult immunosuppression or malignancy in our patient.http://dx.doi.org/10.1155/2017/2396068 |
| spellingShingle | Rafael Garcia-Carretero Blanca San Jose Montano Cerebellar Involvement in an Immunocompetent Patient Presenting with Progressive Multifocal Leukoencephalopathy Case Reports in Neurological Medicine |
| title | Cerebellar Involvement in an Immunocompetent Patient Presenting with Progressive Multifocal Leukoencephalopathy |
| title_full | Cerebellar Involvement in an Immunocompetent Patient Presenting with Progressive Multifocal Leukoencephalopathy |
| title_fullStr | Cerebellar Involvement in an Immunocompetent Patient Presenting with Progressive Multifocal Leukoencephalopathy |
| title_full_unstemmed | Cerebellar Involvement in an Immunocompetent Patient Presenting with Progressive Multifocal Leukoencephalopathy |
| title_short | Cerebellar Involvement in an Immunocompetent Patient Presenting with Progressive Multifocal Leukoencephalopathy |
| title_sort | cerebellar involvement in an immunocompetent patient presenting with progressive multifocal leukoencephalopathy |
| url | http://dx.doi.org/10.1155/2017/2396068 |
| work_keys_str_mv | AT rafaelgarciacarretero cerebellarinvolvementinanimmunocompetentpatientpresentingwithprogressivemultifocalleukoencephalopathy AT blancasanjosemontano cerebellarinvolvementinanimmunocompetentpatientpresentingwithprogressivemultifocalleukoencephalopathy |