Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway
Oxidative stress refers to an imbalance between oxidative capacity and antioxidant capacity, leading to oxidative damage to proteins, lipids, and DNA, which can result in cell senescence or death. It is closely associated with the occurrence and development of various diseases, including cardiovascu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1548073/full |
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| author | Jie Cui Haonan Li Tianyi Zhang Fengli Lin Meiyun Chen Guimin Zhang Zhong Feng Zhong Feng Zhong Feng Zhong Feng |
| author_facet | Jie Cui Haonan Li Tianyi Zhang Fengli Lin Meiyun Chen Guimin Zhang Zhong Feng Zhong Feng Zhong Feng Zhong Feng |
| author_sort | Jie Cui |
| collection | DOAJ |
| description | Oxidative stress refers to an imbalance between oxidative capacity and antioxidant capacity, leading to oxidative damage to proteins, lipids, and DNA, which can result in cell senescence or death. It is closely associated with the occurrence and development of various diseases, including cardiovascular diseases, nephropathy, malignant tumors, neurodegenerative diseases, hypertension, diabetes, and inflammatory diseases. Curcumin is a natural polyphenol compound of β-diketone, which has a wide range of pharmacological activities such as anti-inflammatory, antibacterial, anti-oxidative stress, anti-tumor, anti-fibrosis, and hypolipidemic, demonstrating broad research and development value. It has a wide range of biological targets and can bind to various endogenous biomolecules. Additionally, it maintains the redox balance primarily by scavenging ROS, enhancing the activity of antioxidant enzymes, inhibiting lipid peroxidation, and chelating metal ions. This paper systematically describes the antioxidative stress mechanisms of curcumin from the perspective of signaling pathways, focusing on the Keap1-Nrf2/ARE, NF-κB, NOX, MAPK and other pathways. The study also discusses potential pathway targets and the complex crosstalk among these pathways, aiming to provide insights for further research on curcumin’s antioxidant mechanisms and its clinical applications. |
| format | Article |
| id | doaj-art-64233aa52f3b4fcf8581be1bbb8a3a5b |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-64233aa52f3b4fcf8581be1bbb8a3a5b2025-08-20T02:09:02ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-04-011610.3389/fphar.2025.15480731548073Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathwayJie Cui0Haonan Li1Tianyi Zhang2Fengli Lin3Meiyun Chen4Guimin Zhang5Zhong Feng6Zhong Feng7Zhong Feng8Zhong Feng9School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, ChinaLunan Pharmaceutical Group Co., Ltd., Linyi, ChinaSchool of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, ChinaGraduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen, ChinaLunan Pharmaceutical Group Co., Ltd., Linyi, ChinaOxidative stress refers to an imbalance between oxidative capacity and antioxidant capacity, leading to oxidative damage to proteins, lipids, and DNA, which can result in cell senescence or death. It is closely associated with the occurrence and development of various diseases, including cardiovascular diseases, nephropathy, malignant tumors, neurodegenerative diseases, hypertension, diabetes, and inflammatory diseases. Curcumin is a natural polyphenol compound of β-diketone, which has a wide range of pharmacological activities such as anti-inflammatory, antibacterial, anti-oxidative stress, anti-tumor, anti-fibrosis, and hypolipidemic, demonstrating broad research and development value. It has a wide range of biological targets and can bind to various endogenous biomolecules. Additionally, it maintains the redox balance primarily by scavenging ROS, enhancing the activity of antioxidant enzymes, inhibiting lipid peroxidation, and chelating metal ions. This paper systematically describes the antioxidative stress mechanisms of curcumin from the perspective of signaling pathways, focusing on the Keap1-Nrf2/ARE, NF-κB, NOX, MAPK and other pathways. The study also discusses potential pathway targets and the complex crosstalk among these pathways, aiming to provide insights for further research on curcumin’s antioxidant mechanisms and its clinical applications.https://www.frontiersin.org/articles/10.3389/fphar.2025.1548073/fullcurcuminoxidative stressKeap1-Nrf2/ARENF-κBNOXMAPK |
| spellingShingle | Jie Cui Haonan Li Tianyi Zhang Fengli Lin Meiyun Chen Guimin Zhang Zhong Feng Zhong Feng Zhong Feng Zhong Feng Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway Frontiers in Pharmacology curcumin oxidative stress Keap1-Nrf2/ARE NF-κB NOX MAPK |
| title | Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway |
| title_full | Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway |
| title_fullStr | Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway |
| title_full_unstemmed | Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway |
| title_short | Research progress on the mechanism of curcumin anti-oxidative stress based on signaling pathway |
| title_sort | research progress on the mechanism of curcumin anti oxidative stress based on signaling pathway |
| topic | curcumin oxidative stress Keap1-Nrf2/ARE NF-κB NOX MAPK |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1548073/full |
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