Tolerance-Inducing Strategies in Islet Transplantation
Allogeneic islet transplantation is a promising approach for restoring normoglycemia in type 1 diabetic patients. Current use of immunosuppressive therapies for management of islet transplant recipients can be counterintuitive to islet function and can lead to complications in the long term. The ind...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/396524 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849412548160389120 |
|---|---|
| author | Sumantha Bhatt John J. Fung Lina Lu Shiguang Qian |
| author_facet | Sumantha Bhatt John J. Fung Lina Lu Shiguang Qian |
| author_sort | Sumantha Bhatt |
| collection | DOAJ |
| description | Allogeneic islet transplantation is a promising approach for restoring normoglycemia in type 1 diabetic patients. Current use of immunosuppressive therapies for management of islet transplant recipients can be counterintuitive to islet function and can lead to complications in the long term. The induction of donor-specific tolerance eliminates the dependency on immunosuppression and allows recipients to retain responses to foreign antigens. The mechanisms by which tolerance is achieved involve the deletion of donor-reactive T cells, induction of T-cell anergy, immune deviation, and generation of regulatory T cells. This review will outline the various methods used for inducing donor-specific tolerance in islet transplantation and will highlight the previously unforeseen potential of tissue stromal cells in promoting islet engraftment. |
| format | Article |
| id | doaj-art-6421e148476e42178fa4a886ec38f58c |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-6421e148476e42178fa4a886ec38f58c2025-08-20T03:34:25ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/396524396524Tolerance-Inducing Strategies in Islet TransplantationSumantha Bhatt0John J. Fung1Lina Lu2Shiguang Qian3Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USADepartment of General Surgery, Transplant Center, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USADepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USADepartment of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USAAllogeneic islet transplantation is a promising approach for restoring normoglycemia in type 1 diabetic patients. Current use of immunosuppressive therapies for management of islet transplant recipients can be counterintuitive to islet function and can lead to complications in the long term. The induction of donor-specific tolerance eliminates the dependency on immunosuppression and allows recipients to retain responses to foreign antigens. The mechanisms by which tolerance is achieved involve the deletion of donor-reactive T cells, induction of T-cell anergy, immune deviation, and generation of regulatory T cells. This review will outline the various methods used for inducing donor-specific tolerance in islet transplantation and will highlight the previously unforeseen potential of tissue stromal cells in promoting islet engraftment.http://dx.doi.org/10.1155/2012/396524 |
| spellingShingle | Sumantha Bhatt John J. Fung Lina Lu Shiguang Qian Tolerance-Inducing Strategies in Islet Transplantation International Journal of Endocrinology |
| title | Tolerance-Inducing Strategies in Islet Transplantation |
| title_full | Tolerance-Inducing Strategies in Islet Transplantation |
| title_fullStr | Tolerance-Inducing Strategies in Islet Transplantation |
| title_full_unstemmed | Tolerance-Inducing Strategies in Islet Transplantation |
| title_short | Tolerance-Inducing Strategies in Islet Transplantation |
| title_sort | tolerance inducing strategies in islet transplantation |
| url | http://dx.doi.org/10.1155/2012/396524 |
| work_keys_str_mv | AT sumanthabhatt toleranceinducingstrategiesinislettransplantation AT johnjfung toleranceinducingstrategiesinislettransplantation AT linalu toleranceinducingstrategiesinislettransplantation AT shiguangqian toleranceinducingstrategiesinislettransplantation |