Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease
Background. The retinal changes have been identified in morphology and function in Parkinson’s disease (PD). However, the controversial results suggest that it is incredible that only using a single method for testing retinal change to evaluate Parkinson’s disease. The aim of this study was to asses...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2018/4163239 |
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| _version_ | 1832555380399407104 |
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| author | Jiang Huang Yi Li Jianjiang Xiao Qin Zhang Guoxu Xu Guanhui Wu Tong Liu Weifeng Luo |
| author_facet | Jiang Huang Yi Li Jianjiang Xiao Qin Zhang Guoxu Xu Guanhui Wu Tong Liu Weifeng Luo |
| author_sort | Jiang Huang |
| collection | DOAJ |
| description | Background. The retinal changes have been identified in morphology and function in Parkinson’s disease (PD). However, the controversial results suggest that it is incredible that only using a single method for testing retinal change to evaluate Parkinson’s disease. The aim of this study was to assess retinal changes and increase the diagnostic efficacy of Parkinson’s disease with a combination of multifocal electroretinogram (mf-ERG) and spectral domain optical coherence tomography (SD-OCT) examinations. Method. Fifty-three PD patients and forty-one healthy controls were enrolled. Subjects were assessed for retinal function using mf-ERG and retinal structure using SD-OCT. Results. The PD patients had a significantly decreased amplitude density of P1 and a delayed implicit time of P1 in some regions. The macular retinal thickness, macular volume, and average RNFL thickness were decreased in PD. The AUC of a single parameter of either retinal function or structure was low. Both of them were higher in diagnostic value to discriminate PD patients. Conclusion. The amplitude density of P1 combined with macular volume can get a high diagnostic efficacy to discriminate between participants with or without PD. It indicates that a combination of mf-ERG and SD-OCT provides a good clinical biomarker for diagnosis of PD. |
| format | Article |
| id | doaj-art-64210d38a41d4bc48f72f8a342787c67 |
| institution | Kabale University |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-64210d38a41d4bc48f72f8a342787c672025-02-03T05:48:23ZengWileyParkinson's Disease2090-80832042-00802018-01-01201810.1155/2018/41632394163239Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s DiseaseJiang Huang0Yi Li1Jianjiang Xiao2Qin Zhang3Guoxu Xu4Guanhui Wu5Tong Liu6Weifeng Luo7Department of Ophthalmology, Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Ophthalmology, Huashan Hospital North, Fudan University, Shanghai, ChinaDepartment of Ophthalmology, Huashan Hospital North, Fudan University, Shanghai, ChinaDepartment of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Ophthalmology, Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, ChinaInstitute of Neuroscience, Soochow University, Suzhou, ChinaDepartment of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, ChinaBackground. The retinal changes have been identified in morphology and function in Parkinson’s disease (PD). However, the controversial results suggest that it is incredible that only using a single method for testing retinal change to evaluate Parkinson’s disease. The aim of this study was to assess retinal changes and increase the diagnostic efficacy of Parkinson’s disease with a combination of multifocal electroretinogram (mf-ERG) and spectral domain optical coherence tomography (SD-OCT) examinations. Method. Fifty-three PD patients and forty-one healthy controls were enrolled. Subjects were assessed for retinal function using mf-ERG and retinal structure using SD-OCT. Results. The PD patients had a significantly decreased amplitude density of P1 and a delayed implicit time of P1 in some regions. The macular retinal thickness, macular volume, and average RNFL thickness were decreased in PD. The AUC of a single parameter of either retinal function or structure was low. Both of them were higher in diagnostic value to discriminate PD patients. Conclusion. The amplitude density of P1 combined with macular volume can get a high diagnostic efficacy to discriminate between participants with or without PD. It indicates that a combination of mf-ERG and SD-OCT provides a good clinical biomarker for diagnosis of PD.http://dx.doi.org/10.1155/2018/4163239 |
| spellingShingle | Jiang Huang Yi Li Jianjiang Xiao Qin Zhang Guoxu Xu Guanhui Wu Tong Liu Weifeng Luo Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease Parkinson's Disease |
| title | Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease |
| title_full | Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease |
| title_fullStr | Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease |
| title_full_unstemmed | Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease |
| title_short | Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease |
| title_sort | combination of multifocal electroretinogram and spectral domain oct can increase diagnostic efficacy of parkinson s disease |
| url | http://dx.doi.org/10.1155/2018/4163239 |
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