Improved Fracture Healing in Patients with Concomitant Traumatic Brain Injury: Proven or Not?
Over the last 3 decades, scientific evidence advocates an association between traumatic brain injury (TBI) and accelerated fracture healing. Multiple clinical and preclinical studies have shown an enhanced callus formation and an increased callus volume in patients, respectively, rats with concomita...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/204842 |
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| author | Martijn Hofman Guido Koopmans Philipp Kobbe Martijn Poeze Hagen Andruszkow Peter R. G. Brink Hans-Christoph Pape |
| author_facet | Martijn Hofman Guido Koopmans Philipp Kobbe Martijn Poeze Hagen Andruszkow Peter R. G. Brink Hans-Christoph Pape |
| author_sort | Martijn Hofman |
| collection | DOAJ |
| description | Over the last 3 decades, scientific evidence advocates an association between traumatic brain injury (TBI) and accelerated fracture healing. Multiple clinical and preclinical studies have shown an enhanced callus formation and an increased callus volume in patients, respectively, rats with concomitant TBI. Over time, different substances (cytokines, hormones, etc.) were in focus to elucidate the relationship between TBI and fracture healing. Until now, the mechanism behind this relationship is not fully clarified and a consensus on which substance plays the key role could not be attained in the literature. In this review, we will give an overview of current concepts and opinions on this topic published in the last decade and both clinical and pathophysiological theories will be discussed. |
| format | Article |
| id | doaj-art-64201a4563004fbcb737bcebd7dffd1d |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-64201a4563004fbcb737bcebd7dffd1d2025-08-20T03:34:25ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/204842204842Improved Fracture Healing in Patients with Concomitant Traumatic Brain Injury: Proven or Not?Martijn Hofman0Guido Koopmans1Philipp Kobbe2Martijn Poeze3Hagen Andruszkow4Peter R. G. Brink5Hans-Christoph Pape6Department of Orthopaedic Trauma, University of Aachen Medical Center, Pauwelsstrasse 30, 52074 Aachen, GermanyAlgiax Pharmaceuticals GmbH, Max-Planck-Strasse 15a, 40699 Erkrath, GermanyDepartment of Orthopaedic Trauma, University of Aachen Medical Center, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Trauma Surgery, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, NetherlandsDepartment of Orthopaedic Trauma, University of Aachen Medical Center, Pauwelsstrasse 30, 52074 Aachen, GermanyDepartment of Trauma Surgery, Maastricht University Medical Center, P.O. Box 5800, 6202 AZ Maastricht, NetherlandsDepartment of Orthopaedic Trauma, University of Aachen Medical Center, Pauwelsstrasse 30, 52074 Aachen, GermanyOver the last 3 decades, scientific evidence advocates an association between traumatic brain injury (TBI) and accelerated fracture healing. Multiple clinical and preclinical studies have shown an enhanced callus formation and an increased callus volume in patients, respectively, rats with concomitant TBI. Over time, different substances (cytokines, hormones, etc.) were in focus to elucidate the relationship between TBI and fracture healing. Until now, the mechanism behind this relationship is not fully clarified and a consensus on which substance plays the key role could not be attained in the literature. In this review, we will give an overview of current concepts and opinions on this topic published in the last decade and both clinical and pathophysiological theories will be discussed.http://dx.doi.org/10.1155/2015/204842 |
| spellingShingle | Martijn Hofman Guido Koopmans Philipp Kobbe Martijn Poeze Hagen Andruszkow Peter R. G. Brink Hans-Christoph Pape Improved Fracture Healing in Patients with Concomitant Traumatic Brain Injury: Proven or Not? Mediators of Inflammation |
| title | Improved Fracture Healing in Patients with Concomitant Traumatic Brain Injury: Proven or Not? |
| title_full | Improved Fracture Healing in Patients with Concomitant Traumatic Brain Injury: Proven or Not? |
| title_fullStr | Improved Fracture Healing in Patients with Concomitant Traumatic Brain Injury: Proven or Not? |
| title_full_unstemmed | Improved Fracture Healing in Patients with Concomitant Traumatic Brain Injury: Proven or Not? |
| title_short | Improved Fracture Healing in Patients with Concomitant Traumatic Brain Injury: Proven or Not? |
| title_sort | improved fracture healing in patients with concomitant traumatic brain injury proven or not |
| url | http://dx.doi.org/10.1155/2015/204842 |
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