GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in metabolic dysfunction-associated steatohepatitis livers

GOLM1 promotes cholesterol gallstone formation via ABCG5-mediated cholesterol efflux in metabolic dysfunction-associated steatohepatitis livers

Background/Aims Metabolic dysfunction-associated steatohepatitis (MASH) is a significant risk factor for gallstone formation, but mechanisms underlying MASH-related gallstone formation remain unclear. Golgi membrane protein 1 (GOLM1) participates in hepatic cholesterol metabolism and is upregulated...

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Main Authors: Yi-Tong Li, Wei-Qing Shao, Zhen-Mei Chen, Xiao-Chen Ma, Chen-He Yi, Bao-Rui Tao, Bo Zhang, Yue Ma, Guo Zhang, Rui Zhang, Yan Geng, Jing Lin, Jin-Hong Chen
Format: Article
Language:English
Published: Korean Association for the Study of the Liver 2025-04-01
Series:Clinical and Molecular Hepatology
Subjects:
metabolic dysfunction-associated steatohepatitis
gallstones
metabolism
golgi membrane protein 1
atp binding cassette transporter subfamily g member 5
Online Access:http://e-cmh.org/upload/pdf/cmh-2024-0657.pdf
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