The use of an interleukin 1 inhibitor in a patient with atypical course of periodic fever
The article presents a case of periodic fever (PF) in a 35-year-old patient, who did not have hereditary and proven genetic factors of the disease, which was characterized by an atypical course with variable in duration and frequency severe abdominal pain and febrile fever attacks, increased acute p...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
IMA-PRESS LLC
2021-06-01
|
| Series: | Современная ревматология |
| Subjects: | |
| Online Access: | https://mrj.ima-press.net/mrj/article/view/1153 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849691612996698112 |
|---|---|
| author | M. S. Eliseev O. V. Zhelyabina A. M. Novikova M. N. Chikina M. K. Kurbanmagomedov M. M. Urumova E. V. Nikolaeva S. O. Salugina E. S. Fedorov E. L. Nasonov A. M. Lila |
| author_facet | M. S. Eliseev O. V. Zhelyabina A. M. Novikova M. N. Chikina M. K. Kurbanmagomedov M. M. Urumova E. V. Nikolaeva S. O. Salugina E. S. Fedorov E. L. Nasonov A. M. Lila |
| author_sort | M. S. Eliseev |
| collection | DOAJ |
| description | The article presents a case of periodic fever (PF) in a 35-year-old patient, who did not have hereditary and proven genetic factors of the disease, which was characterized by an atypical course with variable in duration and frequency severe abdominal pain and febrile fever attacks, increased acute phase reactants and ineffectiveness of colchicine intake. Differential diagnosis with a wide range of febrile conditions was performed. Daily subcutaneous therapy of interleukin 1 inhibitor (iIL1) at a dose of 100 mg was used as a diagnostic marker to confirm the diagnosis of PF. As a result of the therapy, a rapid (within a few hours after injection) relief of the current attack of the disease, normalization of serum CRP levels, and further complete control over the disease (no relapses) were achieved. Our observation shows that a positive response to iIL1 therapy can serve as a diagnostic marker of PF. |
| format | Article |
| id | doaj-art-641c2818d76e414281cf9f5a14bd85a8 |
| institution | DOAJ |
| issn | 1996-7012 2310-158X |
| language | Russian |
| publishDate | 2021-06-01 |
| publisher | IMA-PRESS LLC |
| record_format | Article |
| series | Современная ревматология |
| spelling | doaj-art-641c2818d76e414281cf9f5a14bd85a82025-08-20T03:20:59ZrusIMA-PRESS LLCСовременная ревматология1996-70122310-158X2021-06-01153818510.14412/1996-7012-2021-3-81-852367The use of an interleukin 1 inhibitor in a patient with atypical course of periodic feverM. S. Eliseev0O. V. Zhelyabina1A. M. Novikova2M. N. Chikina3M. K. Kurbanmagomedov4M. M. Urumova5E. V. Nikolaeva6S. O. Salugina7E. S. Fedorov8E. L. Nasonov9A. M. Lila10V.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of RheumatologyV.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)V.A. Nasonova Research Institute of Rheumatology; Department of rheumatology Russian Medical Academy of Continuing Professional EducationThe article presents a case of periodic fever (PF) in a 35-year-old patient, who did not have hereditary and proven genetic factors of the disease, which was characterized by an atypical course with variable in duration and frequency severe abdominal pain and febrile fever attacks, increased acute phase reactants and ineffectiveness of colchicine intake. Differential diagnosis with a wide range of febrile conditions was performed. Daily subcutaneous therapy of interleukin 1 inhibitor (iIL1) at a dose of 100 mg was used as a diagnostic marker to confirm the diagnosis of PF. As a result of the therapy, a rapid (within a few hours after injection) relief of the current attack of the disease, normalization of serum CRP levels, and further complete control over the disease (no relapses) were achieved. Our observation shows that a positive response to iIL1 therapy can serve as a diagnostic marker of PF.https://mrj.ima-press.net/mrj/article/view/1153periodic feverinterleukin 1 inhibitorcolchicinediagnosticstreatment |
| spellingShingle | M. S. Eliseev O. V. Zhelyabina A. M. Novikova M. N. Chikina M. K. Kurbanmagomedov M. M. Urumova E. V. Nikolaeva S. O. Salugina E. S. Fedorov E. L. Nasonov A. M. Lila The use of an interleukin 1 inhibitor in a patient with atypical course of periodic fever Современная ревматология periodic fever interleukin 1 inhibitor colchicine diagnostics treatment |
| title | The use of an interleukin 1 inhibitor in a patient with atypical course of periodic fever |
| title_full | The use of an interleukin 1 inhibitor in a patient with atypical course of periodic fever |
| title_fullStr | The use of an interleukin 1 inhibitor in a patient with atypical course of periodic fever |
| title_full_unstemmed | The use of an interleukin 1 inhibitor in a patient with atypical course of periodic fever |
| title_short | The use of an interleukin 1 inhibitor in a patient with atypical course of periodic fever |
| title_sort | use of an interleukin 1 inhibitor in a patient with atypical course of periodic fever |
| topic | periodic fever interleukin 1 inhibitor colchicine diagnostics treatment |
| url | https://mrj.ima-press.net/mrj/article/view/1153 |
| work_keys_str_mv | AT mseliseev theuseofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT ovzhelyabina theuseofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT amnovikova theuseofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT mnchikina theuseofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT mkkurbanmagomedov theuseofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT mmurumova theuseofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT evnikolaeva theuseofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT sosalugina theuseofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT esfedorov theuseofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT elnasonov theuseofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT amlila theuseofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT mseliseev useofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT ovzhelyabina useofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT amnovikova useofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT mnchikina useofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT mkkurbanmagomedov useofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT mmurumova useofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT evnikolaeva useofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT sosalugina useofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT esfedorov useofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT elnasonov useofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever AT amlila useofaninterleukin1inhibitorinapatientwithatypicalcourseofperiodicfever |