Synergistic interaction of amphotericin B and betulinic acid against clinically important fungi: evidence from in vitro and in silico techniques

Synergistic interaction of amphotericin B and betulinic acid against clinically important fungi: evidence from in vitro and in silico techniques

ABSTRACT Betulinic acid (BA), in combined application with amphotericin B, shows a synergistic effect against Candida, Aspergillus, Scedosporium, Fusarium, and Mucorales fungi at a concentration as low as 0.125 µg/mL. Amphotericin B showed slightly higher affinity towards BA than toward ergosterol,...

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Main Authors: Bence Rafael, Mónika Homa, Csilla Szebenyi, Csaba Vágvölgyi, Chetna Tyagi, Tamás Papp
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:Microbiology Spectrum
Subjects:
Eagle effect
candidiasis
aspergillosis
mucormycosis
in silico molecular docking
mixed pore formation
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03333-24
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https://journals.asm.org/doi/10.1128/spectrum.03333-24

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