Targeted next-generation sequencing of candidate regions identified by GWAS revealed SNPs associated with IBD in GSDs

Canine Inflammatory bowel disease (IBD) is a chronic multifactorial disease, resulting from complex interactions between the intestinal immune system, microbiota and environmental factors in genetically predisposed dogs. Previously, we identified several single nucleotide polymorphisms (SNP) and reg...

Full description

Saved in:
Bibliographic Details
Main Authors: Atiyeh Peiravan, Mazdak Salavati, Androniki Psifidi, Mellora Sharman, Andrew Kent, Penny Watson, Karin Allenspach, Dirk Werling
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Veterinary Science
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1648911/full
Tags: Add Tag
No Tags, Be the first to tag this record!
_version_ 1849243599228633088
author Atiyeh Peiravan
Mazdak Salavati
Androniki Psifidi
Mellora Sharman
Andrew Kent
Penny Watson
Karin Allenspach
Dirk Werling
author_facet Atiyeh Peiravan
Mazdak Salavati
Androniki Psifidi
Mellora Sharman
Andrew Kent
Penny Watson
Karin Allenspach
Dirk Werling
author_sort Atiyeh Peiravan
collection DOAJ
description Canine Inflammatory bowel disease (IBD) is a chronic multifactorial disease, resulting from complex interactions between the intestinal immune system, microbiota and environmental factors in genetically predisposed dogs. Previously, we identified several single nucleotide polymorphisms (SNP) and regions on chromosomes (Chr) 7, 9, 11 and 13 associated with IBD in German shepherd dogs (GSD) using GWAS and FST association analyses. Here, building on our previous results, we performed a targeted next-generation sequencing (NGS) of a two Mb region on Chr 9 and 11 that included 14 of the newly identified candidate genes, to identify potential functional SNPs that could explain these association signals. Furthermore, correlations between genotype and treatment response were estimated. Results revealed several SNPs in the genes for canine EEF1A1, MDH2, IL3, IL4, IL13 and PDLIM. Based on the known function of their human orthologues, these results further our insight into their potential contribution to the pathogenesis of IBD in dogs. In addition, several pathways involved in innate and adaptive immunity and inflammatory responses (i.e., T helper cell differentiation, Th1 and Th2 activation pathway, communication between innate and adaptive immune cells and differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F), were constructed involving the gene products in the candidate regions for IBD susceptibility. Interestingly, some of the identified SNPs were present in only one outcome group, suggesting that different genetic factors are involved in the pathogenesis of IBD in different treatment response groups. This also highlights potential genetic markers to predict the response in dogs treated for IBD.
format Article
id doaj-art-641607ba98e54b3cb6e61ffc0477e9e2
institution Kabale University
issn 2297-1769
language English
publishDate 2025-08-01
publisher Frontiers Media S.A.
record_format Article
series Frontiers in Veterinary Science
spelling doaj-art-641607ba98e54b3cb6e61ffc0477e9e22025-08-20T03:59:25ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-08-011210.3389/fvets.2025.16489111648911Targeted next-generation sequencing of candidate regions identified by GWAS revealed SNPs associated with IBD in GSDsAtiyeh Peiravan0Mazdak Salavati1Androniki Psifidi2Mellora Sharman3Andrew Kent4Penny Watson5Karin Allenspach6Dirk Werling7Centre for Vaccinology and Regenerative Medicine, Department of Pathology and Pathogen Biology, Royal Veterinary College, University of London, North Mymms, United KingdomDairy Research and Innovation Centre, Scotland’s Rural College, Dumfries, United KingdomDepartment of Clinical Sciences and Services, Royal Veterinary College, University of London, North Mymms, United KingdomVetCT, St John’s Innovation Park, Cambridge, United KingdomQueen’s Veterinary School Hospital, University of Cambridge, Cambridge, United KingdomQueen’s Veterinary School Hospital, University of Cambridge, Cambridge, United KingdomCollege of Veterinary Medicine, University of Georgia, Athens, GA, United StatesCentre for Vaccinology and Regenerative Medicine, Department of Pathology and Pathogen Biology, Royal Veterinary College, University of London, North Mymms, United KingdomCanine Inflammatory bowel disease (IBD) is a chronic multifactorial disease, resulting from complex interactions between the intestinal immune system, microbiota and environmental factors in genetically predisposed dogs. Previously, we identified several single nucleotide polymorphisms (SNP) and regions on chromosomes (Chr) 7, 9, 11 and 13 associated with IBD in German shepherd dogs (GSD) using GWAS and FST association analyses. Here, building on our previous results, we performed a targeted next-generation sequencing (NGS) of a two Mb region on Chr 9 and 11 that included 14 of the newly identified candidate genes, to identify potential functional SNPs that could explain these association signals. Furthermore, correlations between genotype and treatment response were estimated. Results revealed several SNPs in the genes for canine EEF1A1, MDH2, IL3, IL4, IL13 and PDLIM. Based on the known function of their human orthologues, these results further our insight into their potential contribution to the pathogenesis of IBD in dogs. In addition, several pathways involved in innate and adaptive immunity and inflammatory responses (i.e., T helper cell differentiation, Th1 and Th2 activation pathway, communication between innate and adaptive immune cells and differential regulation of cytokine production in intestinal epithelial cells by IL-17A and IL-17F), were constructed involving the gene products in the candidate regions for IBD susceptibility. Interestingly, some of the identified SNPs were present in only one outcome group, suggesting that different genetic factors are involved in the pathogenesis of IBD in different treatment response groups. This also highlights potential genetic markers to predict the response in dogs treated for IBD.https://www.frontiersin.org/articles/10.3389/fvets.2025.1648911/fullinflammatory bowel diseasechronic enteropathyNGSGSDcanine
spellingShingle Atiyeh Peiravan
Mazdak Salavati
Androniki Psifidi
Mellora Sharman
Andrew Kent
Penny Watson
Karin Allenspach
Dirk Werling
Targeted next-generation sequencing of candidate regions identified by GWAS revealed SNPs associated with IBD in GSDs
Frontiers in Veterinary Science
inflammatory bowel disease
chronic enteropathy
NGS
GSD
canine
title Targeted next-generation sequencing of candidate regions identified by GWAS revealed SNPs associated with IBD in GSDs
title_full Targeted next-generation sequencing of candidate regions identified by GWAS revealed SNPs associated with IBD in GSDs
title_fullStr Targeted next-generation sequencing of candidate regions identified by GWAS revealed SNPs associated with IBD in GSDs
title_full_unstemmed Targeted next-generation sequencing of candidate regions identified by GWAS revealed SNPs associated with IBD in GSDs
title_short Targeted next-generation sequencing of candidate regions identified by GWAS revealed SNPs associated with IBD in GSDs
title_sort targeted next generation sequencing of candidate regions identified by gwas revealed snps associated with ibd in gsds
topic inflammatory bowel disease
chronic enteropathy
NGS
GSD
canine
url https://www.frontiersin.org/articles/10.3389/fvets.2025.1648911/full
work_keys_str_mv AT atiyehpeiravan targetednextgenerationsequencingofcandidateregionsidentifiedbygwasrevealedsnpsassociatedwithibdingsds
AT mazdaksalavati targetednextgenerationsequencingofcandidateregionsidentifiedbygwasrevealedsnpsassociatedwithibdingsds
AT andronikipsifidi targetednextgenerationsequencingofcandidateregionsidentifiedbygwasrevealedsnpsassociatedwithibdingsds
AT mellorasharman targetednextgenerationsequencingofcandidateregionsidentifiedbygwasrevealedsnpsassociatedwithibdingsds
AT andrewkent targetednextgenerationsequencingofcandidateregionsidentifiedbygwasrevealedsnpsassociatedwithibdingsds
AT pennywatson targetednextgenerationsequencingofcandidateregionsidentifiedbygwasrevealedsnpsassociatedwithibdingsds
AT karinallenspach targetednextgenerationsequencingofcandidateregionsidentifiedbygwasrevealedsnpsassociatedwithibdingsds
AT dirkwerling targetednextgenerationsequencingofcandidateregionsidentifiedbygwasrevealedsnpsassociatedwithibdingsds