Green Nano-Biotechnology: A New Sustainable Paradigm to Control Dengue Infection

Dengue is a growing mosquito-borne viral disease prevalent in 128 countries, while 3.9 billion people are at high risk of acquiring the infection. With no specific treatment available, the only way to mitigate the risk of dengue infection is through controlling of vector, i.e., Aedes aegypti. Nanote...

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Main Authors: Tanzeel Zohra, Ali Talha Khalil, Faryal Saeed, Bushra Latif, Muhammad Salman, Aamer Ikram, Muhammad Ayaz, H. C. Ananda Murthy
Format: Article
Language:English
Published: Wiley 2022-01-01
Series:Bioinorganic Chemistry and Applications
Online Access:http://dx.doi.org/10.1155/2022/3994340
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author Tanzeel Zohra
Ali Talha Khalil
Faryal Saeed
Bushra Latif
Muhammad Salman
Aamer Ikram
Muhammad Ayaz
H. C. Ananda Murthy
author_facet Tanzeel Zohra
Ali Talha Khalil
Faryal Saeed
Bushra Latif
Muhammad Salman
Aamer Ikram
Muhammad Ayaz
H. C. Ananda Murthy
author_sort Tanzeel Zohra
collection DOAJ
description Dengue is a growing mosquito-borne viral disease prevalent in 128 countries, while 3.9 billion people are at high risk of acquiring the infection. With no specific treatment available, the only way to mitigate the risk of dengue infection is through controlling of vector, i.e., Aedes aegypti. Nanotechnology-based prevention strategies like biopesticides with nanoformulation are now getting popular for preventing dengue fever. Metal nanoparticles (NPs) synthesized by an eco-friendly process, through extracts of medicinal plants have indicated potential anti-dengue applications. Green synthesis of metal NPs is simple, cost-effective, and devoid of hazardous wastes. The recent progress in the phyto-synthesized multifunctional metal NPs for anti-dengue applications has encouraged us to review the available literature and mechanistic aspects of the dengue control using green-synthesized NPs. Furthermore, the molecular bases of the viral inhibition through NPs and the nontarget impacts or hazards with reference to the environmental integrity are discussed in depth. Till date, major focus has been on green synthesis of silver and gold NPs, which need further extension to other innovative composite nanomaterials. Further detailed mechanistic studies are required to critically evaluate the mechanistic insights during the synthesis of the biogenic NPs. Likewise, detailed analysis of the toxicological aspects of NPs and their long-term impact in the environment should be critically assessed.
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spelling doaj-art-641247eb476848a498b86aff72b5abdc2025-08-20T02:23:52ZengWileyBioinorganic Chemistry and Applications1687-479X2022-01-01202210.1155/2022/3994340Green Nano-Biotechnology: A New Sustainable Paradigm to Control Dengue InfectionTanzeel Zohra0Ali Talha Khalil1Faryal Saeed2Bushra Latif3Muhammad Salman4Aamer Ikram5Muhammad Ayaz6H. C. Ananda Murthy7Public Health Laboratories DivisionDepartment of PathologyDepartment of BiotechnologyPublic Health Laboratories DivisionPublic Health Laboratories DivisionPublic Health Laboratories DivisionDepartment of PharmacyDepartment of Applied ChemistryDengue is a growing mosquito-borne viral disease prevalent in 128 countries, while 3.9 billion people are at high risk of acquiring the infection. With no specific treatment available, the only way to mitigate the risk of dengue infection is through controlling of vector, i.e., Aedes aegypti. Nanotechnology-based prevention strategies like biopesticides with nanoformulation are now getting popular for preventing dengue fever. Metal nanoparticles (NPs) synthesized by an eco-friendly process, through extracts of medicinal plants have indicated potential anti-dengue applications. Green synthesis of metal NPs is simple, cost-effective, and devoid of hazardous wastes. The recent progress in the phyto-synthesized multifunctional metal NPs for anti-dengue applications has encouraged us to review the available literature and mechanistic aspects of the dengue control using green-synthesized NPs. Furthermore, the molecular bases of the viral inhibition through NPs and the nontarget impacts or hazards with reference to the environmental integrity are discussed in depth. Till date, major focus has been on green synthesis of silver and gold NPs, which need further extension to other innovative composite nanomaterials. Further detailed mechanistic studies are required to critically evaluate the mechanistic insights during the synthesis of the biogenic NPs. Likewise, detailed analysis of the toxicological aspects of NPs and their long-term impact in the environment should be critically assessed.http://dx.doi.org/10.1155/2022/3994340
spellingShingle Tanzeel Zohra
Ali Talha Khalil
Faryal Saeed
Bushra Latif
Muhammad Salman
Aamer Ikram
Muhammad Ayaz
H. C. Ananda Murthy
Green Nano-Biotechnology: A New Sustainable Paradigm to Control Dengue Infection
Bioinorganic Chemistry and Applications
title Green Nano-Biotechnology: A New Sustainable Paradigm to Control Dengue Infection
title_full Green Nano-Biotechnology: A New Sustainable Paradigm to Control Dengue Infection
title_fullStr Green Nano-Biotechnology: A New Sustainable Paradigm to Control Dengue Infection
title_full_unstemmed Green Nano-Biotechnology: A New Sustainable Paradigm to Control Dengue Infection
title_short Green Nano-Biotechnology: A New Sustainable Paradigm to Control Dengue Infection
title_sort green nano biotechnology a new sustainable paradigm to control dengue infection
url http://dx.doi.org/10.1155/2022/3994340
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