Liver developmental microenvironment promotes iHSC generation from human iPSCs

Abstract Hepatic stellate cells (HSCs) are liver-specific mesenchymal cells that play a crucial role in liver formation and regeneration, as well as in different pathological diseases. However, the limited source of primary HSCs (pHSCs) and the suboptimal functionality of induced HSCs (iHSCs) by exi...

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Bibliographic Details
Main Authors: Di Ye, Min Ding, Yu-Mu Song, Heng-Xing Meng, Wen-Hao Chen, Jian-Yun Ge, Yun-Wen Zheng
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-09026-7
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