Factors influencing the occurrence of ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus: a case-control study
Abstract Objective To investigate the risk factors for ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus. Methods A total of 112 elderly patients with hypertension and type 2 diabetes, treated at Jiangmen Central Hospital from January 2023 to December 2023, were sele...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12883-025-04022-w |
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| author | Chujun Li Yuzhen Chen Xiuli Ou Tianhui You |
| author_facet | Chujun Li Yuzhen Chen Xiuli Ou Tianhui You |
| author_sort | Chujun Li |
| collection | DOAJ |
| description | Abstract Objective To investigate the risk factors for ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus. Methods A total of 112 elderly patients with hypertension and type 2 diabetes, treated at Jiangmen Central Hospital from January 2023 to December 2023, were selected and categorized into a stroke group and a non-stroke group, each comprising 56 patients. The two groups were examined for demographic data, risk variables were evaluated by multifactorial logistic regression analysis, and the predictive value was determined using ROC curves. Results The comparison of hyperhomocysteinemia (HHcy), fibrinogen (FIB), and high-density lipoprotein cholesterol (HDL-C) between the non-stroke and stroke groups revealed statistically significant differences (P < 0.05). Logistic regression analysis indicated that HHcy (OR 16.936; 95% CI 1.946–146.071; P = 0.010), FIB (OR 1.773; 95% CI 1.238–2.540; P = 0.002), and HDL-C (OR 0.182; 95% CI 0.043–0.775; P = 0.021) were significant factors in the onset of ischemic stroke among elderly patients with hypertension and type 2 diabetes. ROC curve analysis revealed that the area under the curve (AUC) for FIB, HDL-C, and HHcy in diagnosing stroke associated with hypertension and type 2 diabetes mellitus in the elderly were 0.704, 0.640, and 0.598, respectively, while the AUC for the combined diagnosis of all three was 0.784. Conclusions HHcy, FIB, and HDL-C independently influence the occurrence of ischemic stroke in elderly patients with hypertension combined with type 2 diabetes mellitus, and their combined enhanced predictive capability for ischemic stroke occurrence. |
| format | Article |
| id | doaj-art-640d72357d0847e3813a3d08d979f5de |
| institution | Kabale University |
| issn | 1471-2377 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj-art-640d72357d0847e3813a3d08d979f5de2025-01-26T12:39:28ZengBMCBMC Neurology1471-23772025-01-0125111010.1186/s12883-025-04022-wFactors influencing the occurrence of ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus: a case-control studyChujun Li0Yuzhen Chen1Xiuli Ou2Tianhui You3College of Nursing, Guangdong Pharmaceutical UniversityNursing Department, Jiangmen Central HospitalCollege of Nursing, Guangdong Pharmaceutical UniversityCollege of Continuing Education, Guangdong Pharmaceutical UniversityAbstract Objective To investigate the risk factors for ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus. Methods A total of 112 elderly patients with hypertension and type 2 diabetes, treated at Jiangmen Central Hospital from January 2023 to December 2023, were selected and categorized into a stroke group and a non-stroke group, each comprising 56 patients. The two groups were examined for demographic data, risk variables were evaluated by multifactorial logistic regression analysis, and the predictive value was determined using ROC curves. Results The comparison of hyperhomocysteinemia (HHcy), fibrinogen (FIB), and high-density lipoprotein cholesterol (HDL-C) between the non-stroke and stroke groups revealed statistically significant differences (P < 0.05). Logistic regression analysis indicated that HHcy (OR 16.936; 95% CI 1.946–146.071; P = 0.010), FIB (OR 1.773; 95% CI 1.238–2.540; P = 0.002), and HDL-C (OR 0.182; 95% CI 0.043–0.775; P = 0.021) were significant factors in the onset of ischemic stroke among elderly patients with hypertension and type 2 diabetes. ROC curve analysis revealed that the area under the curve (AUC) for FIB, HDL-C, and HHcy in diagnosing stroke associated with hypertension and type 2 diabetes mellitus in the elderly were 0.704, 0.640, and 0.598, respectively, while the AUC for the combined diagnosis of all three was 0.784. Conclusions HHcy, FIB, and HDL-C independently influence the occurrence of ischemic stroke in elderly patients with hypertension combined with type 2 diabetes mellitus, and their combined enhanced predictive capability for ischemic stroke occurrence.https://doi.org/10.1186/s12883-025-04022-wElderlyHypertension and type 2 diabetes mellitusIschemic strokeInfluential factors |
| spellingShingle | Chujun Li Yuzhen Chen Xiuli Ou Tianhui You Factors influencing the occurrence of ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus: a case-control study BMC Neurology Elderly Hypertension and type 2 diabetes mellitus Ischemic stroke Influential factors |
| title | Factors influencing the occurrence of ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus: a case-control study |
| title_full | Factors influencing the occurrence of ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus: a case-control study |
| title_fullStr | Factors influencing the occurrence of ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus: a case-control study |
| title_full_unstemmed | Factors influencing the occurrence of ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus: a case-control study |
| title_short | Factors influencing the occurrence of ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus: a case-control study |
| title_sort | factors influencing the occurrence of ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus a case control study |
| topic | Elderly Hypertension and type 2 diabetes mellitus Ischemic stroke Influential factors |
| url | https://doi.org/10.1186/s12883-025-04022-w |
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