Exercise Improves Spatial Learning and Memory Performance through the Central GLP-1 Receptors
The glucagon-like peptide 1 (GLP-1) is a hormone which is produced in the enteroendocrine L-cells in the ileum and the neurons of nucleus tractus solitarius (NTS) in the brain which has numerous metabolic effects. The central GLP-1R’s role in cognitive functioning is well known. On the contrary, it...
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| Format: | Article |
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Wiley
2022-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2022/2900628 |
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| author | Majid Taati Peyman Esmaeili Fard Barzegar Abbas Raisi |
| author_facet | Majid Taati Peyman Esmaeili Fard Barzegar Abbas Raisi |
| author_sort | Majid Taati |
| collection | DOAJ |
| description | The glucagon-like peptide 1 (GLP-1) is a hormone which is produced in the enteroendocrine L-cells in the ileum and the neurons of nucleus tractus solitarius (NTS) in the brain which has numerous metabolic effects. The central GLP-1R’s role in cognitive functioning is well known. On the contrary, it has been shown that exercise has positive effects on brain function. So, we decided to elucidate whether the central GLP-1 has a role in memory and learning. Thirty-two rats were used in this experiment in 4 groups. After anesthetizing the rats, the right lateral ventricle was detected, and a cannula was directed to the ventricle. Ten micrograms of exendin-3 or sterile saline, according to the group, was injected via ICV once daily for seven days. The rats in the exercise group considered an exercise period of one hour each day (17 meters per minute) for seven consecutive days. To evaluate the performance of memory and learning, a standard Morris water maze (MWM) tank was utilized. According to the results, the TE-exendin group showed a statistically significant difference from the TE-SAL group in both parameters of latency and time in the zone. In summary, memory and learning were improved by GLP-1R in the exercise group, but not in the sedentary group, which we can hypothesize that exercise can affect memory and learning through this pathway. |
| format | Article |
| id | doaj-art-640236565eb9419c8ac8a9b56598710c |
| institution | Kabale University |
| issn | 1875-8584 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-640236565eb9419c8ac8a9b56598710c2025-08-20T03:34:25ZengWileyBehavioural Neurology1875-85842022-01-01202210.1155/2022/2900628Exercise Improves Spatial Learning and Memory Performance through the Central GLP-1 ReceptorsMajid Taati0Peyman Esmaeili Fard Barzegar1Abbas Raisi2Department of PhysiologyDepartment of Clinical SciencesDepartment of Clinical SciencesThe glucagon-like peptide 1 (GLP-1) is a hormone which is produced in the enteroendocrine L-cells in the ileum and the neurons of nucleus tractus solitarius (NTS) in the brain which has numerous metabolic effects. The central GLP-1R’s role in cognitive functioning is well known. On the contrary, it has been shown that exercise has positive effects on brain function. So, we decided to elucidate whether the central GLP-1 has a role in memory and learning. Thirty-two rats were used in this experiment in 4 groups. After anesthetizing the rats, the right lateral ventricle was detected, and a cannula was directed to the ventricle. Ten micrograms of exendin-3 or sterile saline, according to the group, was injected via ICV once daily for seven days. The rats in the exercise group considered an exercise period of one hour each day (17 meters per minute) for seven consecutive days. To evaluate the performance of memory and learning, a standard Morris water maze (MWM) tank was utilized. According to the results, the TE-exendin group showed a statistically significant difference from the TE-SAL group in both parameters of latency and time in the zone. In summary, memory and learning were improved by GLP-1R in the exercise group, but not in the sedentary group, which we can hypothesize that exercise can affect memory and learning through this pathway.http://dx.doi.org/10.1155/2022/2900628 |
| spellingShingle | Majid Taati Peyman Esmaeili Fard Barzegar Abbas Raisi Exercise Improves Spatial Learning and Memory Performance through the Central GLP-1 Receptors Behavioural Neurology |
| title | Exercise Improves Spatial Learning and Memory Performance through the Central GLP-1 Receptors |
| title_full | Exercise Improves Spatial Learning and Memory Performance through the Central GLP-1 Receptors |
| title_fullStr | Exercise Improves Spatial Learning and Memory Performance through the Central GLP-1 Receptors |
| title_full_unstemmed | Exercise Improves Spatial Learning and Memory Performance through the Central GLP-1 Receptors |
| title_short | Exercise Improves Spatial Learning and Memory Performance through the Central GLP-1 Receptors |
| title_sort | exercise improves spatial learning and memory performance through the central glp 1 receptors |
| url | http://dx.doi.org/10.1155/2022/2900628 |
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