Extracellular vesicles derived from dental follicle stem cells regulate tooth eruption by inhibiting osteoclast differentiation
Tooth eruption as a crucial part in tooth development and regeneration is accompanied by ongoing osteogenesis and osteoclast activity. The dental follicle (DF) surrounding the developing tooth harbors dental follicle stem cells (DFSCs) which play a crucial role in maintaining bone remodeling. Howeve...
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| Language: | English |
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1503481/full |
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| author | Meng Sun Meng Sun Yiru Yu Yiru Yu Weixing Zhang Yi Ding Yi Ding Ang Li Ang Li Ye Li |
| author_facet | Meng Sun Meng Sun Yiru Yu Yiru Yu Weixing Zhang Yi Ding Yi Ding Ang Li Ang Li Ye Li |
| author_sort | Meng Sun |
| collection | DOAJ |
| description | Tooth eruption as a crucial part in tooth development and regeneration is accompanied by ongoing osteogenesis and osteoclast activity. The dental follicle (DF) surrounding the developing tooth harbors dental follicle stem cells (DFSCs) which play a crucial role in maintaining bone remodeling. However, the mechanisms through which they regulate the balance between osteogenesis and osteoclast activity during tooth eruption remain poorly understood. Notably, extracellular vesicles (EVs) in bone homeostasis are considered essential. Our study revealed that the DFSCs could modulate tooth eruption by inhibiting osteoclast differentiation via EVs. Further investigation showed that EVs from DFSCs could inhibit osteoclast differentiation through the ANXA1-PPARγ-CEBPα pathway. Animal experiments indicated that EVs from DFSCs and the cargo ANXA1 affected tooth eruption. In summary, this study suggests the critical role of the dental follicle in tooth eruption through EVs, which may provide therapeutic targets for abnormal tooth eruption and effective approaches for the eruption of regenerated teeth. |
| format | Article |
| id | doaj-art-63fee1a6e1ad415a80077561d6e33920 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-63fee1a6e1ad415a80077561d6e339202025-01-06T07:49:31ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-12-011210.3389/fcell.2024.15034811503481Extracellular vesicles derived from dental follicle stem cells regulate tooth eruption by inhibiting osteoclast differentiationMeng Sun0Meng Sun1Yiru Yu2Yiru Yu3Weixing Zhang4Yi Ding5Yi Ding6Ang Li7Ang Li8Ye Li9Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Periodontology, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Periodontology, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaDepartment of Periodontology, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Periodontology, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Periodontology, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shaanxi, ChinaKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, ChinaTooth eruption as a crucial part in tooth development and regeneration is accompanied by ongoing osteogenesis and osteoclast activity. The dental follicle (DF) surrounding the developing tooth harbors dental follicle stem cells (DFSCs) which play a crucial role in maintaining bone remodeling. However, the mechanisms through which they regulate the balance between osteogenesis and osteoclast activity during tooth eruption remain poorly understood. Notably, extracellular vesicles (EVs) in bone homeostasis are considered essential. Our study revealed that the DFSCs could modulate tooth eruption by inhibiting osteoclast differentiation via EVs. Further investigation showed that EVs from DFSCs could inhibit osteoclast differentiation through the ANXA1-PPARγ-CEBPα pathway. Animal experiments indicated that EVs from DFSCs and the cargo ANXA1 affected tooth eruption. In summary, this study suggests the critical role of the dental follicle in tooth eruption through EVs, which may provide therapeutic targets for abnormal tooth eruption and effective approaches for the eruption of regenerated teeth.https://www.frontiersin.org/articles/10.3389/fcell.2024.1503481/fulltooth eruptiondental follicleextracellular vesicleosteoclast differentiationtooth development |
| spellingShingle | Meng Sun Meng Sun Yiru Yu Yiru Yu Weixing Zhang Yi Ding Yi Ding Ang Li Ang Li Ye Li Extracellular vesicles derived from dental follicle stem cells regulate tooth eruption by inhibiting osteoclast differentiation Frontiers in Cell and Developmental Biology tooth eruption dental follicle extracellular vesicle osteoclast differentiation tooth development |
| title | Extracellular vesicles derived from dental follicle stem cells regulate tooth eruption by inhibiting osteoclast differentiation |
| title_full | Extracellular vesicles derived from dental follicle stem cells regulate tooth eruption by inhibiting osteoclast differentiation |
| title_fullStr | Extracellular vesicles derived from dental follicle stem cells regulate tooth eruption by inhibiting osteoclast differentiation |
| title_full_unstemmed | Extracellular vesicles derived from dental follicle stem cells regulate tooth eruption by inhibiting osteoclast differentiation |
| title_short | Extracellular vesicles derived from dental follicle stem cells regulate tooth eruption by inhibiting osteoclast differentiation |
| title_sort | extracellular vesicles derived from dental follicle stem cells regulate tooth eruption by inhibiting osteoclast differentiation |
| topic | tooth eruption dental follicle extracellular vesicle osteoclast differentiation tooth development |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1503481/full |
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