Cx58 is associated with the metastasis of non-small cell lung cancer via MEF2B/Cx58 axis
Connexins (Cxs), also known as gap junction proteins, are structurally related transmembrane proteins and have been implicated in carcinogenesis. Although some evidence suggests that these proteins are tumor suppressors due to their reduced expression in cancers, recent research indicates their comp...
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| Format: | Article |
| Language: | English |
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China Science Publishing & Media Ltd.
2025-04-01
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| Series: | Acta Biochimica et Biophysica Sinica |
| Subjects: | |
| Online Access: | https://www.sciengine.com/doi/10.3724/abbs.2025049 |
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| _version_ | 1849735886882734080 |
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| author | Tan Fen Chen Juan Sun Lunquan Zhang Lu Zhou Rui |
| author_facet | Tan Fen Chen Juan Sun Lunquan Zhang Lu Zhou Rui |
| author_sort | Tan Fen |
| collection | DOAJ |
| description | Connexins (Cxs), also known as gap junction proteins, are structurally related transmembrane proteins and have been implicated in carcinogenesis. Although some evidence suggests that these proteins are tumor suppressors due to their reduced expression in cancers, recent research indicates their complicated roles in tumor progression during different stages, including metastasis. Here, we show that Cx58, which is upregulated in non-small cell lung cancer (NSCLC), is modulated by myocyte-enhancer binding factor 2B (MEF2B). Either Cx58 or MEF2B knockdown attenuates the migration and invasion of NSCLC cells by inducing cytoskeleton rearrangement. Additionally, the prometastatic role of Cx58 in NSCLC is demonstrated in vivo. In conclusion, our findings suggest that Cx58 is transcriptionally activated by MEF2B and is involved in the metastasis of NSCLC by regulating cytoskeleton organization. Targeting the MEF2B/Cx58 axis may be exploited as a modality for improving NSCLC therapy. |
| format | Article |
| id | doaj-art-63fbeeb144a34b8aa3c96350e9eae5ff |
| institution | DOAJ |
| issn | 1672-9145 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | China Science Publishing & Media Ltd. |
| record_format | Article |
| series | Acta Biochimica et Biophysica Sinica |
| spelling | doaj-art-63fbeeb144a34b8aa3c96350e9eae5ff2025-08-20T03:07:25ZengChina Science Publishing & Media Ltd.Acta Biochimica et Biophysica Sinica1672-91452025-04-01571292130310.3724/abbs.202504920d259ccCx58 is associated with the metastasis of non-small cell lung cancer via MEF2B/Cx58 axisTan Fen0Chen Juan1Sun Lunquan2Zhang Lu3Zhou Rui4["Department of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha 410011, China"]["Department of Pulmonary and Critical Care Medicine, Shenzhen People’s Hospital, Shenzhen 518020, China"]["Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha 410008, China"]["Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China","Shanghai Key Laboratory of Thoracic Tumor Biotherapy, , Shanghai 200030, China"]["of Respiratory and Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha 410011, China"]Connexins (Cxs), also known as gap junction proteins, are structurally related transmembrane proteins and have been implicated in carcinogenesis. Although some evidence suggests that these proteins are tumor suppressors due to their reduced expression in cancers, recent research indicates their complicated roles in tumor progression during different stages, including metastasis. Here, we show that Cx58, which is upregulated in non-small cell lung cancer (NSCLC), is modulated by myocyte-enhancer binding factor 2B (MEF2B). Either Cx58 or MEF2B knockdown attenuates the migration and invasion of NSCLC cells by inducing cytoskeleton rearrangement. Additionally, the prometastatic role of Cx58 in NSCLC is demonstrated in vivo. In conclusion, our findings suggest that Cx58 is transcriptionally activated by MEF2B and is involved in the metastasis of NSCLC by regulating cytoskeleton organization. Targeting the MEF2B/Cx58 axis may be exploited as a modality for improving NSCLC therapy.https://www.sciengine.com/doi/10.3724/abbs.2025049connexin58NSCLCmetastasisMEF2B |
| spellingShingle | Tan Fen Chen Juan Sun Lunquan Zhang Lu Zhou Rui Cx58 is associated with the metastasis of non-small cell lung cancer via MEF2B/Cx58 axis Acta Biochimica et Biophysica Sinica connexin58 NSCLC metastasis MEF2B |
| title | Cx58 is associated with the metastasis of non-small cell lung cancer via MEF2B/Cx58 axis |
| title_full | Cx58 is associated with the metastasis of non-small cell lung cancer via MEF2B/Cx58 axis |
| title_fullStr | Cx58 is associated with the metastasis of non-small cell lung cancer via MEF2B/Cx58 axis |
| title_full_unstemmed | Cx58 is associated with the metastasis of non-small cell lung cancer via MEF2B/Cx58 axis |
| title_short | Cx58 is associated with the metastasis of non-small cell lung cancer via MEF2B/Cx58 axis |
| title_sort | cx58 is associated with the metastasis of non small cell lung cancer via mef2b cx58 axis |
| topic | connexin58 NSCLC metastasis MEF2B |
| url | https://www.sciengine.com/doi/10.3724/abbs.2025049 |
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