Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctions
Microplastics are pollutants that occur in various environments and habitats. Inflammatory bowel disease (IBD) is a chronic inflammatory disease accompanied with diarrhea, and the number of patients has increased worldwide. In this study, manufactured fragmented polyethylene-microplastics in the siz...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Current Research in Toxicology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666027X25000039 |
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| author | Minkyoung Sung Yeon-Ji Lee Soo-Eun Sung Kyung-Ku Kang Jae Woo Park Yujeong Lee Dongmin Kim Sunjong Lee Joo-Hee Choi Sijoon Lee |
| author_facet | Minkyoung Sung Yeon-Ji Lee Soo-Eun Sung Kyung-Ku Kang Jae Woo Park Yujeong Lee Dongmin Kim Sunjong Lee Joo-Hee Choi Sijoon Lee |
| author_sort | Minkyoung Sung |
| collection | DOAJ |
| description | Microplastics are pollutants that occur in various environments and habitats. Inflammatory bowel disease (IBD) is a chronic inflammatory disease accompanied with diarrhea, and the number of patients has increased worldwide. In this study, manufactured fragmented polyethylene-microplastics in the size range of 10–30 ㎛, were oxidized by exposure to ultraviolet light, and then administered to a dextran sodium sulfate-induced colitis mouse model to observe the effects of polyethylene-microplastics on IBD. In the microplastics-treated groups, an increase in disease activity index score, histopathological score, and a decrease in the areas of goblet cells were observed. In addition, the tight junction proteins, ZO-1 and Occludin, were significantly decreased, whereas MPO was significantly increased. Interestingly, E-cadherin, which is an adheren junction, was also decreased, presumably because of the physical effects of microplastics. The results suggest that polyethylene-microplastics worsen IBD and microplastics can affect not only tight junctions, but also adheren junctions. |
| format | Article |
| id | doaj-art-63ecd7eb12964932a6a5ae3ccd795dbb |
| institution | Kabale University |
| issn | 2666-027X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Toxicology |
| spelling | doaj-art-63ecd7eb12964932a6a5ae3ccd795dbb2025-01-30T05:14:58ZengElsevierCurrent Research in Toxicology2666-027X2025-01-018100217Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctionsMinkyoung Sung0Yeon-Ji Lee1Soo-Eun Sung2Kyung-Ku Kang3Jae Woo Park4Yujeong Lee5Dongmin Kim6Sunjong Lee7Joo-Hee Choi8Sijoon Lee9Preclinical Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061 South KoreaPreclinical Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061 South Korea; Medical Convergence Materials Commercialization Center, Gyeongbuk Technopark, Gyeongsan-si, Gyeongbuk 38408, South KoreaPreclinical Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061 South KoreaPreclinical Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061 South KoreaPreclinical Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061 South KoreaPreclinical Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061 South KoreaKorea Institute of Industrial Technology, Cheonan 31056, South KoreaKorea Institute of Industrial Technology, Cheonan 31056, South KoreaPreclinical Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061 South Korea; Corresponding authors.Preclinical Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 41061 South Korea; Corresponding authors.Microplastics are pollutants that occur in various environments and habitats. Inflammatory bowel disease (IBD) is a chronic inflammatory disease accompanied with diarrhea, and the number of patients has increased worldwide. In this study, manufactured fragmented polyethylene-microplastics in the size range of 10–30 ㎛, were oxidized by exposure to ultraviolet light, and then administered to a dextran sodium sulfate-induced colitis mouse model to observe the effects of polyethylene-microplastics on IBD. In the microplastics-treated groups, an increase in disease activity index score, histopathological score, and a decrease in the areas of goblet cells were observed. In addition, the tight junction proteins, ZO-1 and Occludin, were significantly decreased, whereas MPO was significantly increased. Interestingly, E-cadherin, which is an adheren junction, was also decreased, presumably because of the physical effects of microplastics. The results suggest that polyethylene-microplastics worsen IBD and microplastics can affect not only tight junctions, but also adheren junctions.http://www.sciencedirect.com/science/article/pii/S2666027X25000039MicroplasticInflammatory Bowel DiseaseEnvironmental factorTight junctionAdheren junction |
| spellingShingle | Minkyoung Sung Yeon-Ji Lee Soo-Eun Sung Kyung-Ku Kang Jae Woo Park Yujeong Lee Dongmin Kim Sunjong Lee Joo-Hee Choi Sijoon Lee Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctions Current Research in Toxicology Microplastic Inflammatory Bowel Disease Environmental factor Tight junction Adheren junction |
| title | Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctions |
| title_full | Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctions |
| title_fullStr | Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctions |
| title_full_unstemmed | Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctions |
| title_short | Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctions |
| title_sort | exacerbation of polyethylene microplastics in animal models of dss induced colitis through damage to intestinal epithelial cell conjunctions |
| topic | Microplastic Inflammatory Bowel Disease Environmental factor Tight junction Adheren junction |
| url | http://www.sciencedirect.com/science/article/pii/S2666027X25000039 |
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