The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis.
<h4>Background</h4>Genetic polymorphism is suggested to be associated with human physical performance. The angiotensin I-converting enzyme insertion/deletion (ACE I/D) polymorphism and the α-actinin-3 gene (ACTN3) R577X polymorphism have been most widely studied for such association anal...
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054685&type=printable |
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| author | Fang Ma Yu Yang Xiangwei Li Feng Zhou Cong Gao Mufei Li Lei Gao |
| author_facet | Fang Ma Yu Yang Xiangwei Li Feng Zhou Cong Gao Mufei Li Lei Gao |
| author_sort | Fang Ma |
| collection | DOAJ |
| description | <h4>Background</h4>Genetic polymorphism is suggested to be associated with human physical performance. The angiotensin I-converting enzyme insertion/deletion (ACE I/D) polymorphism and the α-actinin-3 gene (ACTN3) R577X polymorphism have been most widely studied for such association analysis. However, the findings are frequently heterogeneous. We aim to summarize the associations of ACE I/D and ACTN3 R577X with sport performance by means of meta-analysis.<h4>Methods</h4>We systematically reviewed and quantitatively summarized published studies, until October 31, 2012, on relationship between ACE/ACTN3 genetic polymorphisms and sports performance, respectively.<h4>Results</h4>A total of 366 articles on ACE and 88 articles on ACTN3 were achieved by literature search. A significant association was found for ACE II genotype compared to D allele carriage (DD+ID) with increased possibility of physical performance (OR, 1.23; 95% CI, 1.05-1.45). With respect to sport discipline, the II genotype was found to be associated with performance in endurance athletes (OR, 1.35; 95% CI, 1.17-1.55). On the other hand, no significant association was observed for ACTN3 RR genotype as compared to X allele carriage (XX+RX) (OR, 1.03; 95% CI, 0.92-1.15). However, when restricted the analyses to power events, a significant association was observed (OR, 1.21; 95% CI, 1.03-1.42).<h4>Conclusion</h4>Our results provide more solid evidence for the associations between ACE II genotype and endurance events and between ACTN3 R allele and power events. The findings suggest that the genetic profiles might influence human physical performance. |
| format | Article |
| id | doaj-art-63ea52b04b7240dbb0a92d552904de95 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-63ea52b04b7240dbb0a92d552904de952025-08-20T03:29:10ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0181e5468510.1371/journal.pone.0054685The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis.Fang MaYu YangXiangwei LiFeng ZhouCong GaoMufei LiLei Gao<h4>Background</h4>Genetic polymorphism is suggested to be associated with human physical performance. The angiotensin I-converting enzyme insertion/deletion (ACE I/D) polymorphism and the α-actinin-3 gene (ACTN3) R577X polymorphism have been most widely studied for such association analysis. However, the findings are frequently heterogeneous. We aim to summarize the associations of ACE I/D and ACTN3 R577X with sport performance by means of meta-analysis.<h4>Methods</h4>We systematically reviewed and quantitatively summarized published studies, until October 31, 2012, on relationship between ACE/ACTN3 genetic polymorphisms and sports performance, respectively.<h4>Results</h4>A total of 366 articles on ACE and 88 articles on ACTN3 were achieved by literature search. A significant association was found for ACE II genotype compared to D allele carriage (DD+ID) with increased possibility of physical performance (OR, 1.23; 95% CI, 1.05-1.45). With respect to sport discipline, the II genotype was found to be associated with performance in endurance athletes (OR, 1.35; 95% CI, 1.17-1.55). On the other hand, no significant association was observed for ACTN3 RR genotype as compared to X allele carriage (XX+RX) (OR, 1.03; 95% CI, 0.92-1.15). However, when restricted the analyses to power events, a significant association was observed (OR, 1.21; 95% CI, 1.03-1.42).<h4>Conclusion</h4>Our results provide more solid evidence for the associations between ACE II genotype and endurance events and between ACTN3 R allele and power events. The findings suggest that the genetic profiles might influence human physical performance.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054685&type=printable |
| spellingShingle | Fang Ma Yu Yang Xiangwei Li Feng Zhou Cong Gao Mufei Li Lei Gao The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis. PLoS ONE |
| title | The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis. |
| title_full | The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis. |
| title_fullStr | The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis. |
| title_full_unstemmed | The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis. |
| title_short | The association of sport performance with ACE and ACTN3 genetic polymorphisms: a systematic review and meta-analysis. |
| title_sort | association of sport performance with ace and actn3 genetic polymorphisms a systematic review and meta analysis |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0054685&type=printable |
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