Proposal and operational evaluation of a device for external and internal photodynamic therapy treatments
Photodynamic therapy (PDT) light sources must match their emission spectrum with the absorption spectrum of the photosensitizer, provide precise treatment definition, deliver adequate irradiance, avoid thermal damage, and minimize treatment duration. Additionally, they should be adaptable to differe...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100024004769 |
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| author | Enrique Navarrete de Gálvez Pablo Fonda Pascual José Aguilera Arjona José Ramón de Andrés Díaz María Navarrete de Gálvez Shiran Perera Mohamed María Victoria de Gálvez Aranda |
| author_facet | Enrique Navarrete de Gálvez Pablo Fonda Pascual José Aguilera Arjona José Ramón de Andrés Díaz María Navarrete de Gálvez Shiran Perera Mohamed María Victoria de Gálvez Aranda |
| author_sort | Enrique Navarrete de Gálvez |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) light sources must match their emission spectrum with the absorption spectrum of the photosensitizer, provide precise treatment definition, deliver adequate irradiance, avoid thermal damage, and minimize treatment duration. Additionally, they should be adaptable to different photosensitizers, easy to manipulate, and cost-effective.Current LED sources are difficult to customize, rigid, and primarily designed for broad-area treatments. For localized treatments, laser technology is commonly employed.We propose a customizable and programmable LED-based device that not only meets these specifications but also addresses the limitations of current LED sources for localized treatments. It allows for the connection of a fiber optic terminal for internal treatments and can be fitted with light-diffusing devices capable of treating lesions externally or penetrating them internally. This device is an enhanced version of a previously developed source that has demonstrated efficacy in several pilot studies of photodynamic therapy.The proposed equipment shows significant potential for both medical and research applications, enabling the configuration of emission spectra on demand and the establishment of tailored treatment protocols based on the type of lesion being treated. |
| format | Article |
| id | doaj-art-63e8da0f3b96480eb24dd09133c515fd |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-63e8da0f3b96480eb24dd09133c515fd2025-02-01T04:11:43ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104440Proposal and operational evaluation of a device for external and internal photodynamic therapy treatmentsEnrique Navarrete de Gálvez0Pablo Fonda Pascual1José Aguilera Arjona2José Ramón de Andrés Díaz3María Navarrete de Gálvez4Shiran Perera Mohamed5María Victoria de Gálvez Aranda6Project Engineering Area, Department of Graphic Expression Design and Projects, University of Málaga, Málaga, Spain; Corresponding author at: Project Engineering Area, Department of Graphic Expression Design and Projects, School of Industrial Engineering, University of Málaga, Málaga, Campus Universitario de Teatinos S/N, 29071-Málaga, Spain.Dermatology Department, Gómez Ulla Hospital Central de la Defensa, Madrid, SpainPhotobiological Dermatology Laboratory Medical Research Centre, Department of Dermatology and Medicine, Faculty of Medicine, University of Málaga, Málaga, SpainProject Engineering Area, Department of Graphic Expression Design and Projects, University of Málaga, Málaga, SpainInternal Medicine Service, Hospital Universitario Virgen de la Victoria, Málaga, SpainProject Engineering Area, Department of Graphic Expression Design and Projects, University of Málaga, Málaga, SpainPhotobiological Dermatology Laboratory Medical Research Centre, Department of Dermatology and Medicine, Faculty of Medicine, University of Málaga, Málaga, SpainPhotodynamic therapy (PDT) light sources must match their emission spectrum with the absorption spectrum of the photosensitizer, provide precise treatment definition, deliver adequate irradiance, avoid thermal damage, and minimize treatment duration. Additionally, they should be adaptable to different photosensitizers, easy to manipulate, and cost-effective.Current LED sources are difficult to customize, rigid, and primarily designed for broad-area treatments. For localized treatments, laser technology is commonly employed.We propose a customizable and programmable LED-based device that not only meets these specifications but also addresses the limitations of current LED sources for localized treatments. It allows for the connection of a fiber optic terminal for internal treatments and can be fitted with light-diffusing devices capable of treating lesions externally or penetrating them internally. This device is an enhanced version of a previously developed source that has demonstrated efficacy in several pilot studies of photodynamic therapy.The proposed equipment shows significant potential for both medical and research applications, enabling the configuration of emission spectra on demand and the establishment of tailored treatment protocols based on the type of lesion being treated.http://www.sciencedirect.com/science/article/pii/S1572100024004769Absorption spectrumEmission spectrumLED devicePhotodynamic therapy (PDT)Photosensitizer |
| spellingShingle | Enrique Navarrete de Gálvez Pablo Fonda Pascual José Aguilera Arjona José Ramón de Andrés Díaz María Navarrete de Gálvez Shiran Perera Mohamed María Victoria de Gálvez Aranda Proposal and operational evaluation of a device for external and internal photodynamic therapy treatments Photodiagnosis and Photodynamic Therapy Absorption spectrum Emission spectrum LED device Photodynamic therapy (PDT) Photosensitizer |
| title | Proposal and operational evaluation of a device for external and internal photodynamic therapy treatments |
| title_full | Proposal and operational evaluation of a device for external and internal photodynamic therapy treatments |
| title_fullStr | Proposal and operational evaluation of a device for external and internal photodynamic therapy treatments |
| title_full_unstemmed | Proposal and operational evaluation of a device for external and internal photodynamic therapy treatments |
| title_short | Proposal and operational evaluation of a device for external and internal photodynamic therapy treatments |
| title_sort | proposal and operational evaluation of a device for external and internal photodynamic therapy treatments |
| topic | Absorption spectrum Emission spectrum LED device Photodynamic therapy (PDT) Photosensitizer |
| url | http://www.sciencedirect.com/science/article/pii/S1572100024004769 |
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