hUMSC-Exosomes suppress TREM1-p38 MAPK signaling via HMGB1-dependent mechanisms to reprogram microglial function and promote neuroprotection in ischemic stroke

hUMSC-Exosomes suppress TREM1-p38 MAPK signaling via HMGB1-dependent mechanisms to reprogram microglial function and promote neuroprotection in ischemic stroke

Abstract Background Ischemic stroke induces profound neuroinflammation, where microglial activation exacerbates secondary brain injury. Human umbilical mesenchymal stem cell-derived exosomes (hUMSC-Exos) exhibit therapeutic potential, but their mechanisms in modulating microglial responses remain in...

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Bibliographic Details
Main Authors: Zengyu Zhang, Rong Ji, Zhuohang Liu, Zhiwen Jiang, Min Chu, Yong Wang, Jing Zhao
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Nanobiotechnology
Subjects:
hUMSC-exosomes
Ischemic stroke
TREM1
P38 MAPK signaling
Microglia
Neuroinflammation
Online Access:https://doi.org/10.1186/s12951-025-03652-z
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