The use of biocompatible composite scaffolds in oncology
Modern tissue engineering approaches are aimed at developing scaffolds that contribute to the development of the whole variety of intercellular interactions that imitate those in a real object.The purpose of the study was to collect and summarize the data on the creation and use of three-dimensional...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2022-03-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/2037 |
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| author | O. I. Kit A. Yu. Maksimov I. A. Novikova A. S. Goncharova E. A. Lukbanova A. O. Sitkovskaya V. G. Volovik S. V. Chapek |
| author_facet | O. I. Kit A. Yu. Maksimov I. A. Novikova A. S. Goncharova E. A. Lukbanova A. O. Sitkovskaya V. G. Volovik S. V. Chapek |
| author_sort | O. I. Kit |
| collection | DOAJ |
| description | Modern tissue engineering approaches are aimed at developing scaffolds that contribute to the development of the whole variety of intercellular interactions that imitate those in a real object.The purpose of the study was to collect and summarize the data on the creation and use of three-dimensional cellular matrices.Material and Methods. A systematic literature search was conducted in the PubMed, Medline, Cyber Leninka and Elibrary databases. Out of the 315 articles searched, 38 were selected for this review.Results. A review of studies devoted to the development of three-dimensional composite structures (scaffolds) and their application in the field of cellular technologies was carried out. Methods for the manufacture of biocompatible structures using both natural biomaterials and synthetic ones, including various hydrogels and titanium alloys, were considered, and some physical and chemical characteristics were also discussed. The review discussed possible applications of 3D composite structures in oncology as one of the possible tools for expanding the fundamental understanding of the patterns of development of the malignant process, but also for use in the development of effective methods of treatment and the search for new drugs. The prospects for the use of scaffolds in the field of experimental oncology, namely in the creation of various types of tumor models, were outlined.Conclusion. Currently, three-dimensional culture systems are replacing two-dimensional models. Advances in this direction are associated with the creation and development of various variants of cell matrices that contribute to the solution of a number of applied problems in the field of creating three-dimensional tumor models in vitro and in vivo, therapy of malignant tumors and restorative medicine. |
| format | Article |
| id | doaj-art-63e3fc46f1f34024b387ca9e4ea0bf1d |
| institution | DOAJ |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2022-03-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-63e3fc46f1f34024b387ca9e4ea0bf1d2025-08-20T03:18:24ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682022-03-0121113013610.21294/1814-4861-2022-21-1-130-136969The use of biocompatible composite scaffolds in oncologyO. I. Kit0A. Yu. Maksimov1I. A. Novikova2A. S. Goncharova3E. A. Lukbanova4A. O. Sitkovskaya5V. G. Volovik6S. V. Chapek7National Medical Research Institute of Oncology, the Ministry of Health of the RussiaNational Medical Research Institute of Oncology, the Ministry of Health of the RussiaNational Medical Research Institute of Oncology, the Ministry of Health of the RussiaNational Medical Research Institute of Oncology, the Ministry of Health of the RussiaNational Medical Research Institute of Oncology, the Ministry of Health of the RussiaNational Medical Research Institute of Oncology, the Ministry of Health of the RussiaNational Medical Research Institute of Oncology, the Ministry of Health of the RussiaDon State Technical University, the Ministry of Health of the RussiaModern tissue engineering approaches are aimed at developing scaffolds that contribute to the development of the whole variety of intercellular interactions that imitate those in a real object.The purpose of the study was to collect and summarize the data on the creation and use of three-dimensional cellular matrices.Material and Methods. A systematic literature search was conducted in the PubMed, Medline, Cyber Leninka and Elibrary databases. Out of the 315 articles searched, 38 were selected for this review.Results. A review of studies devoted to the development of three-dimensional composite structures (scaffolds) and their application in the field of cellular technologies was carried out. Methods for the manufacture of biocompatible structures using both natural biomaterials and synthetic ones, including various hydrogels and titanium alloys, were considered, and some physical and chemical characteristics were also discussed. The review discussed possible applications of 3D composite structures in oncology as one of the possible tools for expanding the fundamental understanding of the patterns of development of the malignant process, but also for use in the development of effective methods of treatment and the search for new drugs. The prospects for the use of scaffolds in the field of experimental oncology, namely in the creation of various types of tumor models, were outlined.Conclusion. Currently, three-dimensional culture systems are replacing two-dimensional models. Advances in this direction are associated with the creation and development of various variants of cell matrices that contribute to the solution of a number of applied problems in the field of creating three-dimensional tumor models in vitro and in vivo, therapy of malignant tumors and restorative medicine.https://www.siboncoj.ru/jour/article/view/2037scaffoldcellular matrices3d modelingtumor models |
| spellingShingle | O. I. Kit A. Yu. Maksimov I. A. Novikova A. S. Goncharova E. A. Lukbanova A. O. Sitkovskaya V. G. Volovik S. V. Chapek The use of biocompatible composite scaffolds in oncology Сибирский онкологический журнал scaffold cellular matrices 3d modeling tumor models |
| title | The use of biocompatible composite scaffolds in oncology |
| title_full | The use of biocompatible composite scaffolds in oncology |
| title_fullStr | The use of biocompatible composite scaffolds in oncology |
| title_full_unstemmed | The use of biocompatible composite scaffolds in oncology |
| title_short | The use of biocompatible composite scaffolds in oncology |
| title_sort | use of biocompatible composite scaffolds in oncology |
| topic | scaffold cellular matrices 3d modeling tumor models |
| url | https://www.siboncoj.ru/jour/article/view/2037 |
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