Persistent Methicillin-Susceptible Bacteremia Rapidly Cleared with Cefazolin and Ertapenem Combination Therapy in a Patient with COVID-19
Methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infections (BSIs) are associated with significant morbidity and mortality. MSSA BSIs can rapidly disseminate, resulting in deep-seated infections, prolonged durations of bacteremia, and further metastases. Recently, cefazolin and ertap...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2022/6828538 |
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| author | Dan Ilges Gayathri Krishnan Elvin Geng |
| author_facet | Dan Ilges Gayathri Krishnan Elvin Geng |
| author_sort | Dan Ilges |
| collection | DOAJ |
| description | Methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infections (BSIs) are associated with significant morbidity and mortality. MSSA BSIs can rapidly disseminate, resulting in deep-seated infections, prolonged durations of bacteremia, and further metastases. Recently, cefazolin and ertapenem combination therapy has emerged as a potential therapeutic strategy to sterilize the blood in patients with persistent MSSA bacteremia. Here, we present a patient with COVID-19 pneumonia and concomitant MSSA BSI achieving blood culture sterilization within 24 hours of cefazolin and ertapenem combination therapy initiation following 11 days of positive blood cultures. |
| format | Article |
| id | doaj-art-63df4d3f9ee74d2aa3f5860270240212 |
| institution | OA Journals |
| issn | 2090-6633 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-63df4d3f9ee74d2aa3f58602702402122025-08-20T02:35:16ZengWileyCase Reports in Infectious Diseases2090-66332022-01-01202210.1155/2022/6828538Persistent Methicillin-Susceptible Bacteremia Rapidly Cleared with Cefazolin and Ertapenem Combination Therapy in a Patient with COVID-19Dan Ilges0Gayathri Krishnan1Elvin Geng2Mayo Clinic HospitalWashington University School of MedicineWashington University School of MedicineMethicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infections (BSIs) are associated with significant morbidity and mortality. MSSA BSIs can rapidly disseminate, resulting in deep-seated infections, prolonged durations of bacteremia, and further metastases. Recently, cefazolin and ertapenem combination therapy has emerged as a potential therapeutic strategy to sterilize the blood in patients with persistent MSSA bacteremia. Here, we present a patient with COVID-19 pneumonia and concomitant MSSA BSI achieving blood culture sterilization within 24 hours of cefazolin and ertapenem combination therapy initiation following 11 days of positive blood cultures.http://dx.doi.org/10.1155/2022/6828538 |
| spellingShingle | Dan Ilges Gayathri Krishnan Elvin Geng Persistent Methicillin-Susceptible Bacteremia Rapidly Cleared with Cefazolin and Ertapenem Combination Therapy in a Patient with COVID-19 Case Reports in Infectious Diseases |
| title | Persistent Methicillin-Susceptible Bacteremia Rapidly Cleared with Cefazolin and Ertapenem Combination Therapy in a Patient with COVID-19 |
| title_full | Persistent Methicillin-Susceptible Bacteremia Rapidly Cleared with Cefazolin and Ertapenem Combination Therapy in a Patient with COVID-19 |
| title_fullStr | Persistent Methicillin-Susceptible Bacteremia Rapidly Cleared with Cefazolin and Ertapenem Combination Therapy in a Patient with COVID-19 |
| title_full_unstemmed | Persistent Methicillin-Susceptible Bacteremia Rapidly Cleared with Cefazolin and Ertapenem Combination Therapy in a Patient with COVID-19 |
| title_short | Persistent Methicillin-Susceptible Bacteremia Rapidly Cleared with Cefazolin and Ertapenem Combination Therapy in a Patient with COVID-19 |
| title_sort | persistent methicillin susceptible bacteremia rapidly cleared with cefazolin and ertapenem combination therapy in a patient with covid 19 |
| url | http://dx.doi.org/10.1155/2022/6828538 |
| work_keys_str_mv | AT danilges persistentmethicillinsusceptiblebacteremiarapidlyclearedwithcefazolinandertapenemcombinationtherapyinapatientwithcovid19 AT gayathrikrishnan persistentmethicillinsusceptiblebacteremiarapidlyclearedwithcefazolinandertapenemcombinationtherapyinapatientwithcovid19 AT elvingeng persistentmethicillinsusceptiblebacteremiarapidlyclearedwithcefazolinandertapenemcombinationtherapyinapatientwithcovid19 |