Topotecan Incorporation Into Avocado Oil-based Nanoemulsion Potentiates Its Inhibitory Effect on the Cellular Growth of Various Human Cancer Cells

Topotecan Incorporation Into Avocado Oil-based Nanoemulsion Potentiates Its Inhibitory Effect on the Cellular Growth of Various Human Cancer Cells

Background: The aim is to ameliorate the anticancer activity of topotecan (topoisomerase [TOPO]) by solubilizing it in a nanoemulsion (NE) delivery system containing avocado oil (AO), then to assess its cytotoxicity in MCF-7 breast, HCT116 colon, HeLa cervical, and HepG2 liver cancer cells. Methods:...

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Bibliographic Details
Main Authors: Mayson H. Alkhatib, Hadeel M. Bayoumi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2024-12-01
Series:Biomedical and Biotechnology Research Journal
Subjects:
apoptosis
autophagy
caspase-3
cellular uptake
interleukin-6
Online Access:https://journals.lww.com/10.4103/bbrj.bbrj_287_24
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