The CXCR4 antagonist R54 targets epithelial-mesenchymal transition (EMT) in human ovarian cancer cells.

The CXCR4 antagonist R54 targets epithelial-mesenchymal transition (EMT) in human ovarian cancer cells.

The axis CXCL12-CXCR4 is highly expressed in ovarian cancer where contributes to disease progression. Aim of the work was to evaluate the effect of the newly developed CXCR4 antagonist R54 on human ovarian cancer cells aggressiveness. CXCL12-CXCR4 axis was evaluated in human ovarian cancer cells thr...

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Main Authors: Daniela Russo, Anna Spina, Luigi Portella, Anna Maria Bello, Francesca Galdiero, Anna Maria Trotta, Caterina Ieranò, Giuseppina Rea, Sabrina Chiara Cecere, Elisabetta Coppola, Salvatore Di Maro, Sandro Pignata, Daniela Califano, Stefania Scala
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0314735
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