Acceleration of Ethanol Metabolism by a Patented <i>Bos taurus</i> Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption
Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who in...
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| Format: | Article |
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MDPI AG
2024-10-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/13/19/3207 |
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| author | Bun Tsoi Huan Zhang Chun-Pang So Angel Ka-Kei Lam Christina Chui-Wa Poon Sek-Lun Law Bing-Lou Wong Sai-Wang Seto |
| author_facet | Bun Tsoi Huan Zhang Chun-Pang So Angel Ka-Kei Lam Christina Chui-Wa Poon Sek-Lun Law Bing-Lou Wong Sai-Wang Seto |
| author_sort | Bun Tsoi |
| collection | DOAJ |
| description | Alcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who inevitably need to consume alcohol. In this study, three different models were used to determine the efficacy of a patented alcohol degradation protein (ADP) extracted from <i>Bos taurus</i> on ethanol metabolism. In an ethanol-challenged HepG2 cell model, ADP significantly protected the cell from ethanol-induced toxicity. Subsequently, results demonstrated that ADP significantly alleviated the effect of ethanol, as reflected by the increased distance and activity time of zebrafish during the testing period. Additionally, in a rat model, ADP promoted ethanol degradation at 1 and 2 h after ethanol consumption. Mechanistic studies found that ADP treatment increased ADH and ALDH activity in the gastrointestinal tract. ADP also exhibited potent antioxidation effects by lowering HO-1 expression in the liver. In conclusion, we believe that ADP is a promising product for relieving hangover symptoms after ethanol consumption, with demonstrated safety and effectiveness at the recommended dosage. |
| format | Article |
| id | doaj-art-63d7bd9047cc45f2942c6fd72723becd |
| institution | OA Journals |
| issn | 2304-8158 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj-art-63d7bd9047cc45f2942c6fd72723becd2025-08-20T02:16:50ZengMDPI AGFoods2304-81582024-10-011319320710.3390/foods13193207Acceleration of Ethanol Metabolism by a Patented <i>Bos taurus</i> Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol ConsumptionBun Tsoi0Huan Zhang1Chun-Pang So2Angel Ka-Kei Lam3Christina Chui-Wa Poon4Sek-Lun Law5Bing-Lou Wong6Sai-Wang Seto7Department of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, ChinaDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, ChinaDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, ChinaDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, ChinaDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, ChinaAlcolear Limited, Fotan, New Territories, Hong Kong, ChinaAlcolear Limited, Fotan, New Territories, Hong Kong, ChinaDepartment of Food Science and Nutrition, The Hong Kong Polytechnic University, Hong Kong, ChinaAlcoholic beverages are among the most widely enjoyed leisure drinks around the world. However, irresponsible drinking habits can have detrimental effects on human health. Therefore, exploring strategies to alleviate discomfort following alcohol consumption would be beneficial for individuals who inevitably need to consume alcohol. In this study, three different models were used to determine the efficacy of a patented alcohol degradation protein (ADP) extracted from <i>Bos taurus</i> on ethanol metabolism. In an ethanol-challenged HepG2 cell model, ADP significantly protected the cell from ethanol-induced toxicity. Subsequently, results demonstrated that ADP significantly alleviated the effect of ethanol, as reflected by the increased distance and activity time of zebrafish during the testing period. Additionally, in a rat model, ADP promoted ethanol degradation at 1 and 2 h after ethanol consumption. Mechanistic studies found that ADP treatment increased ADH and ALDH activity in the gastrointestinal tract. ADP also exhibited potent antioxidation effects by lowering HO-1 expression in the liver. In conclusion, we believe that ADP is a promising product for relieving hangover symptoms after ethanol consumption, with demonstrated safety and effectiveness at the recommended dosage.https://www.mdpi.com/2304-8158/13/19/3207alcohol degradationhangoverliver protection |
| spellingShingle | Bun Tsoi Huan Zhang Chun-Pang So Angel Ka-Kei Lam Christina Chui-Wa Poon Sek-Lun Law Bing-Lou Wong Sai-Wang Seto Acceleration of Ethanol Metabolism by a Patented <i>Bos taurus</i> Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption Foods alcohol degradation hangover liver protection |
| title | Acceleration of Ethanol Metabolism by a Patented <i>Bos taurus</i> Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption |
| title_full | Acceleration of Ethanol Metabolism by a Patented <i>Bos taurus</i> Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption |
| title_fullStr | Acceleration of Ethanol Metabolism by a Patented <i>Bos taurus</i> Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption |
| title_full_unstemmed | Acceleration of Ethanol Metabolism by a Patented <i>Bos taurus</i> Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption |
| title_short | Acceleration of Ethanol Metabolism by a Patented <i>Bos taurus</i> Isolated Alcohol Degradation Protein (ADP) on Acute Alcohol Consumption |
| title_sort | acceleration of ethanol metabolism by a patented i bos taurus i isolated alcohol degradation protein adp on acute alcohol consumption |
| topic | alcohol degradation hangover liver protection |
| url | https://www.mdpi.com/2304-8158/13/19/3207 |
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