Case Report: The Alzheimer’s paradox: a clinically stable amnestic syndrome with full biomarker positivity and minimal imaging evidence

We report the case of a 75-year-old patient with a clinically isolated and stable amnestic syndrome over fifteen years, despite a cerebrospinal fluid (CSF) profile strongly consistent with Alzheimer’s disease (AD). Serial PET imaging over two years showed only limited amyloid accumulation, no signif...

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Bibliographic Details
Main Authors: Anna-Chloé Balageas, Johnny Vercouillie, Nicolas Arlicot, Anne-Claire Dupont, Maria-Joao Santiago Ribeiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Medicine
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Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1653232/full
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