Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I
Advanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. Our aim was to characterize the relationship between serum carboxymethyl-lysine (CML), a major circulating AGE, and incident severe walking disability (inability to walk or walking speed <0.4 m/sec) ove...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2012/586385 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562812766912512 |
|---|---|
| author | Kai Sun Richard D. Semba Linda P. Fried Debra A. Schaumberg Luigi Ferrucci Ravi Varadhan |
| author_facet | Kai Sun Richard D. Semba Linda P. Fried Debra A. Schaumberg Luigi Ferrucci Ravi Varadhan |
| author_sort | Kai Sun |
| collection | DOAJ |
| description | Advanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. Our aim was to characterize the relationship between serum carboxymethyl-lysine (CML), a major circulating AGE, and incident severe walking disability (inability to walk or walking speed <0.4 m/sec) over 30 months of followup in 394 moderately to severely disabled women, ≥65 years, living in the community in Baltimore, Maryland (the Women’s Health and Aging Study I). During followup, 154 (26.4%) women developed severe walking disability, and 23 women died. Women in the highest quartile of serum CML had increased risk of developing of severe walking disability in a multivariate Cox proportional hazards model, adjusting for age and other potential confounders. Women with elevated serum CML are at an increased risk of developing severe walking disability. AGEs are a potentially modifiable risk factor. Further work is needed to establish a causal relationship between AGEs and walking disability. |
| format | Article |
| id | doaj-art-63ce9f96811b4c02a3e726b345af03df |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-63ce9f96811b4c02a3e726b345af03df2025-02-03T01:21:44ZengWileyJournal of Aging Research2090-22042090-22122012-01-01201210.1155/2012/586385586385Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study IKai Sun0Richard D. Semba1Linda P. Fried2Debra A. Schaumberg3Luigi Ferrucci4Ravi Varadhan5Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USAMailman School of Public Health, Columbia University, New York, NY 10032, USADivision of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USALongitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USADepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USAAdvanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. Our aim was to characterize the relationship between serum carboxymethyl-lysine (CML), a major circulating AGE, and incident severe walking disability (inability to walk or walking speed <0.4 m/sec) over 30 months of followup in 394 moderately to severely disabled women, ≥65 years, living in the community in Baltimore, Maryland (the Women’s Health and Aging Study I). During followup, 154 (26.4%) women developed severe walking disability, and 23 women died. Women in the highest quartile of serum CML had increased risk of developing of severe walking disability in a multivariate Cox proportional hazards model, adjusting for age and other potential confounders. Women with elevated serum CML are at an increased risk of developing severe walking disability. AGEs are a potentially modifiable risk factor. Further work is needed to establish a causal relationship between AGEs and walking disability.http://dx.doi.org/10.1155/2012/586385 |
| spellingShingle | Kai Sun Richard D. Semba Linda P. Fried Debra A. Schaumberg Luigi Ferrucci Ravi Varadhan Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I Journal of Aging Research |
| title | Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I |
| title_full | Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I |
| title_fullStr | Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I |
| title_full_unstemmed | Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I |
| title_short | Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I |
| title_sort | elevated serum carboxymethyl lysine an advanced glycation end product predicts severe walking disability in older women the women s health and aging study i |
| url | http://dx.doi.org/10.1155/2012/586385 |
| work_keys_str_mv | AT kaisun elevatedserumcarboxymethyllysineanadvancedglycationendproductpredictsseverewalkingdisabilityinolderwomenthewomenshealthandagingstudyi AT richarddsemba elevatedserumcarboxymethyllysineanadvancedglycationendproductpredictsseverewalkingdisabilityinolderwomenthewomenshealthandagingstudyi AT lindapfried elevatedserumcarboxymethyllysineanadvancedglycationendproductpredictsseverewalkingdisabilityinolderwomenthewomenshealthandagingstudyi AT debraaschaumberg elevatedserumcarboxymethyllysineanadvancedglycationendproductpredictsseverewalkingdisabilityinolderwomenthewomenshealthandagingstudyi AT luigiferrucci elevatedserumcarboxymethyllysineanadvancedglycationendproductpredictsseverewalkingdisabilityinolderwomenthewomenshealthandagingstudyi AT ravivaradhan elevatedserumcarboxymethyllysineanadvancedglycationendproductpredictsseverewalkingdisabilityinolderwomenthewomenshealthandagingstudyi |