Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I

Advanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. Our aim was to characterize the relationship between serum carboxymethyl-lysine (CML), a major circulating AGE, and incident severe walking disability (inability to walk or walking speed <0.4 m/sec) ove...

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Main Authors: Kai Sun, Richard D. Semba, Linda P. Fried, Debra A. Schaumberg, Luigi Ferrucci, Ravi Varadhan
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Journal of Aging Research
Online Access:http://dx.doi.org/10.1155/2012/586385
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author Kai Sun
Richard D. Semba
Linda P. Fried
Debra A. Schaumberg
Luigi Ferrucci
Ravi Varadhan
author_facet Kai Sun
Richard D. Semba
Linda P. Fried
Debra A. Schaumberg
Luigi Ferrucci
Ravi Varadhan
author_sort Kai Sun
collection DOAJ
description Advanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. Our aim was to characterize the relationship between serum carboxymethyl-lysine (CML), a major circulating AGE, and incident severe walking disability (inability to walk or walking speed <0.4 m/sec) over 30 months of followup in 394 moderately to severely disabled women, ≥65 years, living in the community in Baltimore, Maryland (the Women’s Health and Aging Study I). During followup, 154 (26.4%) women developed severe walking disability, and 23 women died. Women in the highest quartile of serum CML had increased risk of developing of severe walking disability in a multivariate Cox proportional hazards model, adjusting for age and other potential confounders. Women with elevated serum CML are at an increased risk of developing severe walking disability. AGEs are a potentially modifiable risk factor. Further work is needed to establish a causal relationship between AGEs and walking disability.
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spelling doaj-art-63ce9f96811b4c02a3e726b345af03df2025-02-03T01:21:44ZengWileyJournal of Aging Research2090-22042090-22122012-01-01201210.1155/2012/586385586385Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study IKai Sun0Richard D. Semba1Linda P. Fried2Debra A. Schaumberg3Luigi Ferrucci4Ravi Varadhan5Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USAMailman School of Public Health, Columbia University, New York, NY 10032, USADivision of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USALongitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD 21225, USADepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USAAdvanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. Our aim was to characterize the relationship between serum carboxymethyl-lysine (CML), a major circulating AGE, and incident severe walking disability (inability to walk or walking speed <0.4 m/sec) over 30 months of followup in 394 moderately to severely disabled women, ≥65 years, living in the community in Baltimore, Maryland (the Women’s Health and Aging Study I). During followup, 154 (26.4%) women developed severe walking disability, and 23 women died. Women in the highest quartile of serum CML had increased risk of developing of severe walking disability in a multivariate Cox proportional hazards model, adjusting for age and other potential confounders. Women with elevated serum CML are at an increased risk of developing severe walking disability. AGEs are a potentially modifiable risk factor. Further work is needed to establish a causal relationship between AGEs and walking disability.http://dx.doi.org/10.1155/2012/586385
spellingShingle Kai Sun
Richard D. Semba
Linda P. Fried
Debra A. Schaumberg
Luigi Ferrucci
Ravi Varadhan
Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I
Journal of Aging Research
title Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I
title_full Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I
title_fullStr Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I
title_full_unstemmed Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I
title_short Elevated Serum Carboxymethyl-Lysine, an Advanced Glycation End Product, Predicts Severe Walking Disability in Older Women: The Women's Health and Aging Study I
title_sort elevated serum carboxymethyl lysine an advanced glycation end product predicts severe walking disability in older women the women s health and aging study i
url http://dx.doi.org/10.1155/2012/586385
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