Microvascular dysfunction across organs in heart failure with preserved ejection fraction: the PROSE-HFpEF case-control study

Microvascular dysfunction across organs in heart failure with preserved ejection fraction: the PROSE-HFpEF case-control study

Abstract Background Systemic microvascular dysfunction is proposed as a key pathophysiological process in heart failure with preserved ejection fraction (HFpEF). This study compared microvasculature across vascular beds in HFpEF patients and controls. Methods This prospective, case-control study inc...

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Main Authors: Jerremy Weerts, Blanche L. M. Schroen, Arantxa Barandiarán Aizpurua, Tos T. J. M. Berendschot, Lloyd Brandts, Carroll A. B. Webers, Sami O. Simons, Steven J. R. Meex, Ronald Henry, Carla J. H. van der Kallen, Hans-Peter Brunner-La Rocca, Christian Knackstedt, Stephane R. B. Heymans, Rudolf A. de Boer, Vanessa P. M. van Empel, Alfons J. H. M. Houben
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cardiovascular Diabetology
Subjects:
Heart failure with preserved ejection fraction
Diastolic heart failure
Microcirculation
Pathophysiology
Sex differences
HFpEF
Online Access:https://doi.org/10.1186/s12933-025-02850-1
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