Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments
Tinospora cordifolia extract contains antioxidants such as polyphenols, and thus, it has been used as a natural phytochemical antioxidant therapeutic agent. Many of these compounds are insoluble or only partially soluble in water. In this study, we produced a novel aqueous nanoparticle formulation,...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2020/3637098 |
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| author | Jeimmy González-Masís Jorge M. Cubero-Sesin Yendry Regina Corrales-Ureña Sara González-Camacho Nohelia Mora-Ugalde José Roberto Vega-Baudrit Klaus Rischka Virendra Verma Rodolfo J. Gonzalez-Paz |
| author_facet | Jeimmy González-Masís Jorge M. Cubero-Sesin Yendry Regina Corrales-Ureña Sara González-Camacho Nohelia Mora-Ugalde José Roberto Vega-Baudrit Klaus Rischka Virendra Verma Rodolfo J. Gonzalez-Paz |
| author_sort | Jeimmy González-Masís |
| collection | DOAJ |
| description | Tinospora cordifolia extract contains antioxidants such as polyphenols, and thus, it has been used as a natural phytochemical antioxidant therapeutic agent. Many of these compounds are insoluble or only partially soluble in water. In this study, we produced a novel aqueous nanoparticle formulation, with an average particle size of 182.9 ± 3.8 nm, to improve the dispersion of the bioactive compounds in water and to increment its bioavailability. The nanoparticles are composed of polyphenols, alkaloids, and glycosides. We studied the effect of this nanoparticle formulation on mouse 3T3 fibroblast cell viability and New Zealand rabbit dermal irritability tests. Concentrations of 2.5, 25, and 250 µg/mL resulted in similar cell viability to cells in culture media. An intermediate concentration of 12.45 mg/ml was used for the acute dermal irritability test. There were no severe alterations that compromised animal health. These results represent a precedent for application of such nanoparticles derived from plant stems, such as Tinospora cordifolia, in biomedicine and in antiaging cosmetic treatments. |
| format | Article |
| id | doaj-art-63c30ecf5dfd4367b930f91324d75d88 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-63c30ecf5dfd4367b930f91324d75d882025-08-20T03:34:29ZengWileyInternational Journal of Biomaterials1687-87871687-87952020-01-01202010.1155/2020/36370983637098Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant TreatmentsJeimmy González-Masís0Jorge M. Cubero-Sesin1Yendry Regina Corrales-Ureña2Sara González-Camacho3Nohelia Mora-Ugalde4José Roberto Vega-Baudrit5Klaus Rischka6Virendra Verma7Rodolfo J. Gonzalez-Paz8Centro de Investigación y Extensión en Materiales, Escuela de Ciencia e Ingeniería de Los Materiales, Instituto Tecnológico de Costa Rica, Cartago 159-7050, Costa RicaCentro de Investigación y Extensión en Materiales, Escuela de Ciencia e Ingeniería de Los Materiales, Instituto Tecnológico de Costa Rica, Cartago 159-7050, Costa RicaNational Laboratory of Nanotechnology LANOTEC, National Center of High Technology (CeNAT-CONARE), Pavas 1174-1200, San José, Costa RicaBiological Assay Laboratory (LEBi), Universidad de Costa Rica, San José 11501-2060, Costa RicaNational Center for Biotechnological Innovations (CENIBiot), National Center of High Technology (-CeNAT-CONARE), Pavas 1174-1200, San José, Costa RicaNational Laboratory of Nanotechnology LANOTEC, National Center of High Technology (CeNAT-CONARE), Pavas 1174-1200, San José, Costa RicaFraunhofer Institute for Manufacturing Technology and Advanced Materials, Adhesive Bonding Technology and Surfaces, Wiener Straße 12, 28359, Bremen, GermanyAyurvedic Physician Private Clinic & Panchakarma Centre, Varanasi, IndiaNational Laboratory of Nanotechnology LANOTEC, National Center of High Technology (CeNAT-CONARE), Pavas 1174-1200, San José, Costa RicaTinospora cordifolia extract contains antioxidants such as polyphenols, and thus, it has been used as a natural phytochemical antioxidant therapeutic agent. Many of these compounds are insoluble or only partially soluble in water. In this study, we produced a novel aqueous nanoparticle formulation, with an average particle size of 182.9 ± 3.8 nm, to improve the dispersion of the bioactive compounds in water and to increment its bioavailability. The nanoparticles are composed of polyphenols, alkaloids, and glycosides. We studied the effect of this nanoparticle formulation on mouse 3T3 fibroblast cell viability and New Zealand rabbit dermal irritability tests. Concentrations of 2.5, 25, and 250 µg/mL resulted in similar cell viability to cells in culture media. An intermediate concentration of 12.45 mg/ml was used for the acute dermal irritability test. There were no severe alterations that compromised animal health. These results represent a precedent for application of such nanoparticles derived from plant stems, such as Tinospora cordifolia, in biomedicine and in antiaging cosmetic treatments.http://dx.doi.org/10.1155/2020/3637098 |
| spellingShingle | Jeimmy González-Masís Jorge M. Cubero-Sesin Yendry Regina Corrales-Ureña Sara González-Camacho Nohelia Mora-Ugalde José Roberto Vega-Baudrit Klaus Rischka Virendra Verma Rodolfo J. Gonzalez-Paz Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments International Journal of Biomaterials |
| title | Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments |
| title_full | Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments |
| title_fullStr | Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments |
| title_full_unstemmed | Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments |
| title_short | Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments |
| title_sort | nonirritant and cytocompatible tinospora cordifolia nanoparticles for topical antioxidant treatments |
| url | http://dx.doi.org/10.1155/2020/3637098 |
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