Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes
Dermatophytes are fungi responsible for causing superficial infections. In patients with diabetes mellitus (DM), dermatophytosis is usually more severe and recurrent. In the present study, we aimed to investigate the influence of short and long term hypoinsulinemia-hyperglycemia (HH) during experime...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/342345 |
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| author | Thais F. C. Fraga-Silva Camila M. Marchetti Luiza A. N. Mimura Gisele A. Locachevic Márjorie A. Golim James Venturini Maria S. P. Arruda |
| author_facet | Thais F. C. Fraga-Silva Camila M. Marchetti Luiza A. N. Mimura Gisele A. Locachevic Márjorie A. Golim James Venturini Maria S. P. Arruda |
| author_sort | Thais F. C. Fraga-Silva |
| collection | DOAJ |
| description | Dermatophytes are fungi responsible for causing superficial infections. In patients with diabetes mellitus (DM), dermatophytosis is usually more severe and recurrent. In the present study, we aimed to investigate the influence of short and long term hypoinsulinemia-hyperglycemia (HH) during experimental infection by Trichophyton mentagrophytes as well as alterations in the mononuclear phagocytes. Our results showed two distinct profiles of fungal outcome and immune response. Short term HH induced a discrete impaired proinflammatory response by peritoneal adherent cells (PAC) and a delayed fungal clearance. Moreover, long term HH mice showed low and persistent fungal load and a marked reduction in the production of TNF-α by PAC. Furthermore, while the inoculation of TM in non-HH mice triggered high influx of Gr1+ monocytes into the peripheral blood, long term HH mice showed low percentage of these cells. Thus, our results demonstrate that the time of exposure of HH interferes with the TM infection outcome as well as the immunobiology of mononuclear phagocytes, including fresh monocyte recruitment from bone marrow and PAC activity. |
| format | Article |
| id | doaj-art-63c2a0591a3d44df915da5ef6eee7618 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-63c2a0591a3d44df915da5ef6eee76182025-08-20T02:35:16ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/342345342345Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear PhagocytesThais F. C. Fraga-Silva0Camila M. Marchetti1Luiza A. N. Mimura2Gisele A. Locachevic3Márjorie A. Golim4James Venturini5Maria S. P. Arruda6Department of Biological Sciences, School of Sciences, Universidade Estadual Paulista (UNESP), 17033-360 Bauru, SP, BrazilDepartment of Biological Sciences, School of Sciences, Universidade Estadual Paulista (UNESP), 17033-360 Bauru, SP, BrazilDepartment of Microbiology and Immunology, Institute of Biosciences of Botucatu, Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, BrazilDepartment of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP), 14040-903 Ribeirão Preto, SP, BrazilBotucatu Blood Center, Universidade Estadual Paulista (UNESP), 18618-970 Botucatu, SP, BrazilDepartment of Biological Sciences, School of Sciences, Universidade Estadual Paulista (UNESP), 17033-360 Bauru, SP, BrazilDepartment of Biological Sciences, School of Sciences, Universidade Estadual Paulista (UNESP), 17033-360 Bauru, SP, BrazilDermatophytes are fungi responsible for causing superficial infections. In patients with diabetes mellitus (DM), dermatophytosis is usually more severe and recurrent. In the present study, we aimed to investigate the influence of short and long term hypoinsulinemia-hyperglycemia (HH) during experimental infection by Trichophyton mentagrophytes as well as alterations in the mononuclear phagocytes. Our results showed two distinct profiles of fungal outcome and immune response. Short term HH induced a discrete impaired proinflammatory response by peritoneal adherent cells (PAC) and a delayed fungal clearance. Moreover, long term HH mice showed low and persistent fungal load and a marked reduction in the production of TNF-α by PAC. Furthermore, while the inoculation of TM in non-HH mice triggered high influx of Gr1+ monocytes into the peripheral blood, long term HH mice showed low percentage of these cells. Thus, our results demonstrate that the time of exposure of HH interferes with the TM infection outcome as well as the immunobiology of mononuclear phagocytes, including fresh monocyte recruitment from bone marrow and PAC activity.http://dx.doi.org/10.1155/2015/342345 |
| spellingShingle | Thais F. C. Fraga-Silva Camila M. Marchetti Luiza A. N. Mimura Gisele A. Locachevic Márjorie A. Golim James Venturini Maria S. P. Arruda Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes Mediators of Inflammation |
| title | Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes |
| title_full | Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes |
| title_fullStr | Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes |
| title_full_unstemmed | Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes |
| title_short | Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes |
| title_sort | relationship among short and long term of hypoinsulinemia hyperglycemia dermatophytosis and immunobiology of mononuclear phagocytes |
| url | http://dx.doi.org/10.1155/2015/342345 |
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