Metastructure and strain-defect engineered Cu-doped TiOx coating to enhance antibacterial sonodynamic therapy

Metastructure and strain-defect engineered Cu-doped TiOx coating to enhance antibacterial sonodynamic therapy

Sonodynamic therapy (SDT) has attracted widespread attention in treatment of implant-associated infections, one of the key factors leading to implant failure. Nevertheless, constructing efficient ultrasound-triggered coatings on implant surfaces remains a challenge. Herein, an acoustic metastructure...

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Bibliographic Details
Main Authors: Songsong Wang, Ji Tan, Haifeng Zhang, Shiwei Guan, Yibo Zeng, Xiaoshuang Nie, Hongqin Zhu, Shi Qian, Xuanyong Liu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-06-01
Series:Bioactive Materials
Subjects:
Metastructure coating
Lattice strain
Titanium oxide
Sonodynamic therapy
Antibacteria
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25000842
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Summary:Sonodynamic therapy (SDT) has attracted widespread attention in treatment of implant-associated infections, one of the key factors leading to implant failure. Nevertheless, constructing efficient ultrasound-triggered coatings on implant surfaces remains a challenge. Herein, an acoustic metastructure Cu-doped defective titanium oxide coating (Cu-TiOx) with lattice strain was constructed in situ on titanium implant to realize effective sonocatalysis. The redistribution of Cu atoms broke the pristine lattice of TiO2 during the thermal reduction treatment to regulate its energy structure, which favored separation of electron-hole pairs generated by ultrasound radiation to enhance the sonocatalytic generation of reactive oxygen species. In addition, the acoustic metastructure enhanced the absorption of ultrasound by Cu-TiOx metastructure coating, which further promoted its sonocatalytic effect. Thus, Cu-TiOx metastructure coating could efficiently eliminate Staphylococcus aureus and Escherichia coli infections under ultrasonic irradiation in 10 min. Besides, the osteogenic property of implant was significantly improved after infection clearance in vivo. This work provides a fresh perspective on the design of SDT biosurfaces based on metastructure and strain-defect engineering.
ISSN:2452-199X

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