Plastic harmful ingredients reduce the level of neurofilament light chain protein
Population exposure to plastics is increasing, and plasticizers are frequently detected in humans as important ingredients of plastic products. However, patterns of exposure to harmful ingredients of plastics and their effects on neurofilament light chain (NFL), a marker of active brain pathology, a...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325000065 |
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| author | Long Li Xiaoxiu Ma Junwei Liu Yongli Wu |
| author_facet | Long Li Xiaoxiu Ma Junwei Liu Yongli Wu |
| author_sort | Long Li |
| collection | DOAJ |
| description | Population exposure to plastics is increasing, and plasticizers are frequently detected in humans as important ingredients of plastic products. However, patterns of exposure to harmful ingredients of plastics and their effects on neurofilament light chain (NFL), a marker of active brain pathology, are currently inconclusive. Herein, we employed a range of statistical methods to thoroughly investigate the impact of 24 plastic hazardous ingredients and their varying exposure patterns on NFL concentrations in the blood of the general population in 533 participants. Generalized linear model revealed a positive correlation between Mono-isononyl phthalate and Mono (2-Ethyl- 5-Hydroxyhexyl) Phthalate (MEHHP) with NFL. Furthermore, a significant dose-response relationship was observed between MEHHP and NFL, while Butyl paraben and Mono (Hydroxy-Isononyl) Ester exhibited a distinct ''inverted U-shaped'' nonlinear pattern with NFL. Additionally, Weighted Quantile Sum model allowed us to identify the mixed effects of all 24 plastic hazardous ingredients, with Mono(2-Ethyl-5-Oxohexyl) Phthalate, Mono-isobutyl phthalate, Mon butyl Phthalate, Propyl paraben and Triclosan occupying prominent positions. Finally, the latent profile analysis categorized exposures into high, medium, and low patterns, confirming that higher exposure to plastic hazardous ingredients posed a significant risk factor for elevated NFL levels in the blood. Exposure to plastic hazardous ingredients significantly increases the risk of NFL, the present contributes to early detection and intervention to reduce the incidence of neurodevelopmental disorder. |
| format | Article |
| id | doaj-art-63acd45c4ca041659421ce4b540d3158 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-63acd45c4ca041659421ce4b540d31582025-01-23T05:26:03ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117670Plastic harmful ingredients reduce the level of neurofilament light chain proteinLong Li0Xiaoxiu Ma1Junwei Liu2Yongli Wu3Orthopaedics Department of Traditional Chinese Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui 750004, ChinaOrthopaedics Department of Traditional Chinese Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui 750004, ChinaOrthopaedics Department of Traditional Chinese Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui 750004, ChinaOrthopaedics Department of Traditional Chinese Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui 750004, China; Key Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan, Ningxia Hui 750004, China; Corresponding author at: Orthopaedics Department of Traditional Chinese Medicine, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui 750004, China.Population exposure to plastics is increasing, and plasticizers are frequently detected in humans as important ingredients of plastic products. However, patterns of exposure to harmful ingredients of plastics and their effects on neurofilament light chain (NFL), a marker of active brain pathology, are currently inconclusive. Herein, we employed a range of statistical methods to thoroughly investigate the impact of 24 plastic hazardous ingredients and their varying exposure patterns on NFL concentrations in the blood of the general population in 533 participants. Generalized linear model revealed a positive correlation between Mono-isononyl phthalate and Mono (2-Ethyl- 5-Hydroxyhexyl) Phthalate (MEHHP) with NFL. Furthermore, a significant dose-response relationship was observed between MEHHP and NFL, while Butyl paraben and Mono (Hydroxy-Isononyl) Ester exhibited a distinct ''inverted U-shaped'' nonlinear pattern with NFL. Additionally, Weighted Quantile Sum model allowed us to identify the mixed effects of all 24 plastic hazardous ingredients, with Mono(2-Ethyl-5-Oxohexyl) Phthalate, Mono-isobutyl phthalate, Mon butyl Phthalate, Propyl paraben and Triclosan occupying prominent positions. Finally, the latent profile analysis categorized exposures into high, medium, and low patterns, confirming that higher exposure to plastic hazardous ingredients posed a significant risk factor for elevated NFL levels in the blood. Exposure to plastic hazardous ingredients significantly increases the risk of NFL, the present contributes to early detection and intervention to reduce the incidence of neurodevelopmental disorder.http://www.sciencedirect.com/science/article/pii/S0147651325000065Plastic hazardous ingredientsNeurofilament light chainLatent Profile Analysis |
| spellingShingle | Long Li Xiaoxiu Ma Junwei Liu Yongli Wu Plastic harmful ingredients reduce the level of neurofilament light chain protein Ecotoxicology and Environmental Safety Plastic hazardous ingredients Neurofilament light chain Latent Profile Analysis |
| title | Plastic harmful ingredients reduce the level of neurofilament light chain protein |
| title_full | Plastic harmful ingredients reduce the level of neurofilament light chain protein |
| title_fullStr | Plastic harmful ingredients reduce the level of neurofilament light chain protein |
| title_full_unstemmed | Plastic harmful ingredients reduce the level of neurofilament light chain protein |
| title_short | Plastic harmful ingredients reduce the level of neurofilament light chain protein |
| title_sort | plastic harmful ingredients reduce the level of neurofilament light chain protein |
| topic | Plastic hazardous ingredients Neurofilament light chain Latent Profile Analysis |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325000065 |
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