Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model
Premature pubarche can be benign, or it can be an early marker of insulin resistance in some girls. The aim of this study was to evaluate insulin resistance in prepubertal girls presenting with premature pubarche (n = 19; mean age = 6.93 +/- 1.78) as compared to age- and Tanner stage-matched...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2007-04-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2530 |
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| author | Olcay Evliyaoğlu Merih Berberoğlu Pelin Adiyaman Zehra Aycan Gönül Ocal |
| author_facet | Olcay Evliyaoğlu Merih Berberoğlu Pelin Adiyaman Zehra Aycan Gönül Ocal |
| author_sort | Olcay Evliyaoğlu |
| collection | DOAJ |
| description |
Premature pubarche can be benign, or it can be an early marker of insulin resistance in some girls. The aim of this study was to evaluate insulin resistance in prepubertal girls presenting with premature pubarche (n = 19; mean age = 6.93 +/- 1.78) as compared to age- and Tanner stage-matched controls (n = 10; mean age = 7.55 +/- 1.32) using indirect insulin resistance parameters. Two groups were compared by means of oral glucose tolerance test (OGTT), indirect insulin resistance (IR) parameters [homeostasis assessment (HOMA) models: HOMA-IR, glucose/insulin (G/I)] and serum lipid profiles. In the girls with premature pubarche, mean baseline insulin level and HOMA-IR value were significantly higher and G/I ratio was lower than in the control group. IR was observed in 42.1% and in 31.6% according to HOMA-IR value and G/I ratio, respectively. Even at diagnosis, IR was increased in a significant portion of the girls with premature pubarche.
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| format | Article |
| id | doaj-art-63a9112fa24940c2bc56688c5bbc00ba |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2007-04-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-63a9112fa24940c2bc56688c5bbc00ba2025-08-20T02:55:42ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212007-04-01492Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) modelOlcay Evliyaoğlu0Merih BerberoğluPelin AdiyamanZehra AycanGönül OcalDepartment of Pediatric Endocrinology, Ankara University, Faculty of Medicine, Ankara, Turkey. Premature pubarche can be benign, or it can be an early marker of insulin resistance in some girls. The aim of this study was to evaluate insulin resistance in prepubertal girls presenting with premature pubarche (n = 19; mean age = 6.93 +/- 1.78) as compared to age- and Tanner stage-matched controls (n = 10; mean age = 7.55 +/- 1.32) using indirect insulin resistance parameters. Two groups were compared by means of oral glucose tolerance test (OGTT), indirect insulin resistance (IR) parameters [homeostasis assessment (HOMA) models: HOMA-IR, glucose/insulin (G/I)] and serum lipid profiles. In the girls with premature pubarche, mean baseline insulin level and HOMA-IR value were significantly higher and G/I ratio was lower than in the control group. IR was observed in 42.1% and in 31.6% according to HOMA-IR value and G/I ratio, respectively. Even at diagnosis, IR was increased in a significant portion of the girls with premature pubarche. https://turkjpediatr.org/article/view/2530 |
| spellingShingle | Olcay Evliyaoğlu Merih Berberoğlu Pelin Adiyaman Zehra Aycan Gönül Ocal Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model The Turkish Journal of Pediatrics |
| title | Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model |
| title_full | Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model |
| title_fullStr | Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model |
| title_full_unstemmed | Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model |
| title_short | Evaluation of insulin resistance in Turkish girls with premature pubarche using the homeostasis assessment (HOMA) model |
| title_sort | evaluation of insulin resistance in turkish girls with premature pubarche using the homeostasis assessment homa model |
| url | https://turkjpediatr.org/article/view/2530 |
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