Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives
Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer’s disease (AD) and other dementias, Parkinson’s disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington’s disease (HD), spi...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2016/7576292 |
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| _version_ | 1832556338882805760 |
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| author | Marina de Tommaso Lars Arendt-Nielsen Ruth Defrin Miriam Kunz Gisele Pickering Massimiliano Valeriani |
| author_facet | Marina de Tommaso Lars Arendt-Nielsen Ruth Defrin Miriam Kunz Gisele Pickering Massimiliano Valeriani |
| author_sort | Marina de Tommaso |
| collection | DOAJ |
| description | Neurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer’s disease (AD) and other dementias, Parkinson’s disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington’s disease (HD), spinocerebellar ataxia (SCA), and spinal muscular atrophy (SMA), is mainly addressed to motor and cognitive impairment, with special care to vital functions as breathing and feeding. Many of these patients complain of painful symptoms though their origin is variable, and their presence is frequently not considered in the treatment guidelines, leaving their management to the decision of the clinicians alone. However, studies focusing on pain frequency in such disorders suggest a high prevalence of pain in selected populations from 38 to 75% in AD, 40% to 86% in PD, and 19 to 85% in MND. The methods of pain assessment vary between studies so the type of pain has been rarely reported. However, a prevalent nonneuropathic origin of pain emerged for MND and PD. In AD, no data on pain features are available. No controlled therapeutic trials and guidelines are currently available. Given the relevance of pain in neurodegenerative disorders, the comprehensive understanding of mechanisms and predisposing factors, the application and validation of specific scales, and new specific therapeutic trials are needed. |
| format | Article |
| id | doaj-art-63a308e10984418f9ac7a77555aebf55 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-63a308e10984418f9ac7a77555aebf552025-02-03T05:45:46ZengWileyBehavioural Neurology0953-41801875-85842016-01-01201610.1155/2016/75762927576292Pain in Neurodegenerative Disease: Current Knowledge and Future PerspectivesMarina de Tommaso0Lars Arendt-Nielsen1Ruth Defrin2Miriam Kunz3Gisele Pickering4Massimiliano Valeriani5Neurophysiopathology of Pain Section, SMBNOS Department, Bari Aldo Moro University, Bari, ItalyCenter for Sensory-Motor Interaction, Aalborg University, Aalborg, DenmarkDepartment of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, IsraelDepartment of General Practice, Section Gerontology, University Medical Center Groningen, Groningen, NetherlandsCHU Clermont-Ferrand, Centre de Pharmacologie Clinique, Clermont-Ferrand, FranceCenter for Sensory-Motor Interaction, Aalborg University, Aalborg, DenmarkNeurodegenerative diseases are going to increase as the life expectancy is getting longer. The management of neurodegenerative diseases such as Alzheimer’s disease (AD) and other dementias, Parkinson’s disease (PD) and PD related disorders, motor neuron diseases (MND), Huntington’s disease (HD), spinocerebellar ataxia (SCA), and spinal muscular atrophy (SMA), is mainly addressed to motor and cognitive impairment, with special care to vital functions as breathing and feeding. Many of these patients complain of painful symptoms though their origin is variable, and their presence is frequently not considered in the treatment guidelines, leaving their management to the decision of the clinicians alone. However, studies focusing on pain frequency in such disorders suggest a high prevalence of pain in selected populations from 38 to 75% in AD, 40% to 86% in PD, and 19 to 85% in MND. The methods of pain assessment vary between studies so the type of pain has been rarely reported. However, a prevalent nonneuropathic origin of pain emerged for MND and PD. In AD, no data on pain features are available. No controlled therapeutic trials and guidelines are currently available. Given the relevance of pain in neurodegenerative disorders, the comprehensive understanding of mechanisms and predisposing factors, the application and validation of specific scales, and new specific therapeutic trials are needed.http://dx.doi.org/10.1155/2016/7576292 |
| spellingShingle | Marina de Tommaso Lars Arendt-Nielsen Ruth Defrin Miriam Kunz Gisele Pickering Massimiliano Valeriani Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives Behavioural Neurology |
| title | Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives |
| title_full | Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives |
| title_fullStr | Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives |
| title_full_unstemmed | Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives |
| title_short | Pain in Neurodegenerative Disease: Current Knowledge and Future Perspectives |
| title_sort | pain in neurodegenerative disease current knowledge and future perspectives |
| url | http://dx.doi.org/10.1155/2016/7576292 |
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