The alternations of gut microbiota in diabetic kidney disease: insights from a triple comparative cohort
BackgroundDiabetic kidney disease (DKD) exhibits heterogeneous progression, implicating factors beyond hyperglycemia, such as gut microbiota dysbiosis. However, microbial distinctions among biopsy-confirmed pure DKD, DKD with non-diabetic renal disease (DKD+NDRD), and long-term diabetes without neph...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1606700/full |
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| author | Mengqi Wu Xin Zhou Saiping Chen Yuqing Wang Bin Lu Aiping Zhang Yanqin Zhu Min Huang Jiarui Wang Junyi Liu Fenggui Zhu Hong Liu Riyang Lin Riyang Lin |
| author_facet | Mengqi Wu Xin Zhou Saiping Chen Yuqing Wang Bin Lu Aiping Zhang Yanqin Zhu Min Huang Jiarui Wang Junyi Liu Fenggui Zhu Hong Liu Riyang Lin Riyang Lin |
| author_sort | Mengqi Wu |
| collection | DOAJ |
| description | BackgroundDiabetic kidney disease (DKD) exhibits heterogeneous progression, implicating factors beyond hyperglycemia, such as gut microbiota dysbiosis. However, microbial distinctions among biopsy-confirmed pure DKD, DKD with non-diabetic renal disease (DKD+NDRD), and long-term diabetes without nephropathy (DM) remain unclear. This study aimed to identify gut microbial and functional biomarkers differentiating these groups.MethodsWe enrolled 40 biopsy-confirmed participants classified into DKD (n=26), DM (n=8), and DKD+NDRD (n=6) groups. Gut microbiota was profiled using 16S rRNA sequencing. Microbial diversity, composition, and functional prediction (PICRUSt2 analysis) were compared among groups. Biomarkers were identified using LEfSe analysis.ResultsNo significant differences in alpha-diversity (Chao1, Shannon indices) or beta-diversity (PCoA/PCA) were observed among groups. Taxonomic analysis revealed distinct microbial signatures: DKD patients showed enrichment of Olsenella and reduced Faecalibacterium prausnitzii (a short-chain fatty acid producer), while DM patients exhibited higher Roseburia and Flavonifractor. The DKD+NDRD group was uniquely enriched in Prevotella_9. Functional prediction highlighted elevated pyruvate metabolism and bacterial toxin pathways in DKD, contrasting with enhanced linoleic acid metabolism in DM and attenuated endotoxin-related pathways in DKD+NDRD.ConclusionsThis study delineates gut microbiota profiles and functional shifts across DKD, DM, and DKD+NDRD. Key taxa (Olsenella, Prevotella_9) and metabolic pathways (pyruvate, toxin production) may serve as biomarkers for DKD progression and differential diagnosis. The findings underscore the gut-kidney axis’s role in DKD pathogenesis and suggest microbiota-targeted interventions for precision management. Further validation in larger cohorts is warranted. |
| format | Article |
| id | doaj-art-63a264634b3844ae85e9f135e151ba2c |
| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-63a264634b3844ae85e9f135e151ba2c2025-08-20T03:24:44ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-06-011510.3389/fcimb.2025.16067001606700The alternations of gut microbiota in diabetic kidney disease: insights from a triple comparative cohortMengqi Wu0Xin Zhou1Saiping Chen2Yuqing Wang3Bin Lu4Aiping Zhang5Yanqin Zhu6Min Huang7Jiarui Wang8Junyi Liu9Fenggui Zhu10Hong Liu11Riyang Lin12Riyang Lin13Department of Nephrology, Hangzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of General Medicine, Tianshui Wulin Street Community Heal Care Centre, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Hangzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Hangzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Hangzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Hangzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Hangzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Hangzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Hangzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Hangzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Hangzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Hangzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaDepartment of Nephrology, Hangzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaKey Laboratory of Kidney Disease Prevention and Control Technology, Hangzhou, Zhejiang, ChinaBackgroundDiabetic kidney disease (DKD) exhibits heterogeneous progression, implicating factors beyond hyperglycemia, such as gut microbiota dysbiosis. However, microbial distinctions among biopsy-confirmed pure DKD, DKD with non-diabetic renal disease (DKD+NDRD), and long-term diabetes without nephropathy (DM) remain unclear. This study aimed to identify gut microbial and functional biomarkers differentiating these groups.MethodsWe enrolled 40 biopsy-confirmed participants classified into DKD (n=26), DM (n=8), and DKD+NDRD (n=6) groups. Gut microbiota was profiled using 16S rRNA sequencing. Microbial diversity, composition, and functional prediction (PICRUSt2 analysis) were compared among groups. Biomarkers were identified using LEfSe analysis.ResultsNo significant differences in alpha-diversity (Chao1, Shannon indices) or beta-diversity (PCoA/PCA) were observed among groups. Taxonomic analysis revealed distinct microbial signatures: DKD patients showed enrichment of Olsenella and reduced Faecalibacterium prausnitzii (a short-chain fatty acid producer), while DM patients exhibited higher Roseburia and Flavonifractor. The DKD+NDRD group was uniquely enriched in Prevotella_9. Functional prediction highlighted elevated pyruvate metabolism and bacterial toxin pathways in DKD, contrasting with enhanced linoleic acid metabolism in DM and attenuated endotoxin-related pathways in DKD+NDRD.ConclusionsThis study delineates gut microbiota profiles and functional shifts across DKD, DM, and DKD+NDRD. Key taxa (Olsenella, Prevotella_9) and metabolic pathways (pyruvate, toxin production) may serve as biomarkers for DKD progression and differential diagnosis. The findings underscore the gut-kidney axis’s role in DKD pathogenesis and suggest microbiota-targeted interventions for precision management. Further validation in larger cohorts is warranted.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1606700/fulldiabetic kidney disease (DKD)gut microbiota16S rRNAintestinal biomarkerdisease progression |
| spellingShingle | Mengqi Wu Xin Zhou Saiping Chen Yuqing Wang Bin Lu Aiping Zhang Yanqin Zhu Min Huang Jiarui Wang Junyi Liu Fenggui Zhu Hong Liu Riyang Lin Riyang Lin The alternations of gut microbiota in diabetic kidney disease: insights from a triple comparative cohort Frontiers in Cellular and Infection Microbiology diabetic kidney disease (DKD) gut microbiota 16S rRNA intestinal biomarker disease progression |
| title | The alternations of gut microbiota in diabetic kidney disease: insights from a triple comparative cohort |
| title_full | The alternations of gut microbiota in diabetic kidney disease: insights from a triple comparative cohort |
| title_fullStr | The alternations of gut microbiota in diabetic kidney disease: insights from a triple comparative cohort |
| title_full_unstemmed | The alternations of gut microbiota in diabetic kidney disease: insights from a triple comparative cohort |
| title_short | The alternations of gut microbiota in diabetic kidney disease: insights from a triple comparative cohort |
| title_sort | alternations of gut microbiota in diabetic kidney disease insights from a triple comparative cohort |
| topic | diabetic kidney disease (DKD) gut microbiota 16S rRNA intestinal biomarker disease progression |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1606700/full |
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