Structure-activity studies of bispyridinium antinicotinics to select candidates to treat soman intoxication as part of a combined therapy.

Structure-activity studies of bispyridinium antinicotinics to select candidates to treat soman intoxication as part of a combined therapy.

The standard treatment of atropine and oximes is insufficiently effective against all organophosphorus nerve agents. Bispyridinium non-oxime nicotinic antagonists are promising components to add to treatments. One of these, MB327, improves the survival of guinea-pigs after intoxication with tabun, s...

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Bibliographic Details
Main Authors: Simon R Turner, Christopher M Timperley, Mike Bird, A Christopher Green, Matthew E Price, Helen Rice, John E Chad, John E H Tattersall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0318508
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