New Insights into the Anticancer Effects and Toxicogenomic Safety of Two β-Lapachone Derivatives

New Insights into the Anticancer Effects and Toxicogenomic Safety of Two β-Lapachone Derivatives

<b>Background/Objectives:</b> β-Lapachone (β-lap) is an <i>o</i>-naphthoquinone with potent antitumor activity. However, its clinical application is hindered by poor solubility and toxicity. Thiosemicarbazone derivatives of β-lap (BV3 and BV5) have demonstrated enhanced selec...

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Bibliographic Details
Main Authors: José Rivaldo De Lima, Alexandre José Da Silva Góes, Elizabeth Fernanda De Oliveira Borba, Meykson Alexandre da Silva, Rodrigo Ribeiro Alves Caiana, Maria do Desterro Rodrigues, Mariza Severina De Lima Silva, Cristiano Aparecido Chagas, Blandine Baratte, Thomas Robert, Stéphane Bach, Isabelle Ourliac-Garnier, Pascal Marchand, Teresinha Gonçalves Da Silva
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
quinone
thiosemicarbazone
apoptosis
necrosis
kinases
DNA damage
Online Access:https://www.mdpi.com/1424-8247/18/6/837
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