Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis

Neutrophil extracellular trap gene expression signatures identify prognostic and targetable signaling axes for inhibiting pancreatic tumour metastasis

Abstract Tumour associated neutrophils (TANs) promote metastasis through interactions of Neutrophil Extracellular Traps (NETs) with tumour cells. However, molecular details surrounding the interactions between NETs and Pancreatic Ductal Adenocarcinoma (PDAC) cells are poorly understood. Here, we exa...

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Main Authors: Paul C. McDonald, James T. Topham, Shannon Awrey, Hossein Tavakoli, Rebekah Carroll, Wells S. Brown, Zachary J. Gerbec, Steve E. Kalloger, Joanna M. Karasinska, Patricia Tang, Rachel Goodwin, Steven J. M. Jones, Janessa Laskin, Marco A. Marra, Gregg B. Morin, Daniel J. Renouf, David F. Schaeffer, Shoukat Dedhar
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08440-x
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