Preclinical evaluation and preliminary clinical study of 68Ga-NODAGA-NM-01 for PET imaging of PD-L1 expression

Preclinical evaluation and preliminary clinical study of 68Ga-NODAGA-NM-01 for PET imaging of PD-L1 expression

Abstract Background Programmed cell death 1/programmed death ligand-1 (PD-L1)-based immune checkpoint blockade is an effective treatment approach for non-small-cell lung cancer (NSCLC). However, immunohistochemistry does not accurately or dynamically reflect PD-L1 expression owing to its spatiotempo...

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Bibliographic Details
Main Authors: Lingzhou Zhao, Jiali Gong, Sisi Liao, Wenhua Huang, Jinhua Zhao, Yan Xing
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cancer Imaging
Subjects:
Nanobody
Programmed death ligand-1
Non-small-cell lung cancer
PET imaging
Online Access:https://doi.org/10.1186/s40644-025-00826-8
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