Targeting androgen receptor stability and degradation: approaches for developing a therapy for spinal and bulbar muscular atrophy

Abstract Conformational changes of proteins can occur due to mutations or stress conditions, altering their functionality through loss of physiological or gain of pathological function. A Protein Quality Control (PQC) system exists in cells to deal with the accumulation of misfolded proteins and agg...

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Bibliographic Details
Main Authors:	Riccardo Cristofani, Barbara Tedesco, Veronica Ferrari, Marta Chierichetti, Marta Cozzi, Paola Pramaggiore, Laura Cornaggia, Ali Mohamed, Elena Casarotto, Maria Brodnanova, Rocio Magdalena, Prashant Koshal, Margherita Piccolella, Valeria Crippa, Mariarita Galbiati, Angelo Poletti, Paola Rusmini
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Series:	Cell Communication and Signaling
Subjects:	Androgen receptor Polyglutamine Autophagy Degradation
Online Access:	https://doi.org/10.1186/s12964-025-02351-4
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Targeting androgen receptor stability and degradation: approaches for developing a therapy for spinal and bulbar muscular atrophy

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