Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light
Context The emergence of pan-resistant bacteria requires the development of new antibiotics and antibiotic potentiators.Objective This review identifies antibacterial phenolic compounds that have been identified in Asian and Pacific Angiosperms from 1945 to 2023 and analyzes their strengths and spec...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Pharmaceutical Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13880209.2024.2407530 |
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| author | Mazdida Sulaiman Layane Ebehairy Veeranoot Nissapatorn Mohammed Rahmatullah Jhonnel Villegas Helina Jean Dupa Ricksterlie C. Verzosa Karma G. Dolma Muhamad Shabaz Scholastica Lanting Nor Azizun Rusdi Nor Hayati Abdullah Mohammed Khaled Bin Break Teng Jin Khoo Wei Wang Christophe Wiart |
| author_facet | Mazdida Sulaiman Layane Ebehairy Veeranoot Nissapatorn Mohammed Rahmatullah Jhonnel Villegas Helina Jean Dupa Ricksterlie C. Verzosa Karma G. Dolma Muhamad Shabaz Scholastica Lanting Nor Azizun Rusdi Nor Hayati Abdullah Mohammed Khaled Bin Break Teng Jin Khoo Wei Wang Christophe Wiart |
| author_sort | Mazdida Sulaiman |
| collection | DOAJ |
| description | Context The emergence of pan-resistant bacteria requires the development of new antibiotics and antibiotic potentiators.Objective This review identifies antibacterial phenolic compounds that have been identified in Asian and Pacific Angiosperms from 1945 to 2023 and analyzes their strengths and spectra of activity, distributions, molecular masses, solubilities, modes of action, structures-activities, as well as their synergistic effects with antibiotics, toxicities, and clinical potential.Methods All data in this review was compiled from Google Scholar, PubMed, Science Direct, Web of Science, and library search; other sources were excluded. We used the following combination of keywords: ‘Phenolic compound’, ‘Plants’, and ‘Antibacterial’. This produced 736 results. Each result was examined and articles that did not contain information relevant to the topic or coming from non-peer-reviewed journals were excluded. Each of the remaining 467 selected articles was read critically for the information that it contained.Results Out of ∼350 antibacterial phenolic compounds identified, 44 were very strongly active, mainly targeting the cytoplasmic membrane of Gram-positive bacteria, and with a molecular mass between 200 and 400 g/mol. 2-Methoxy-7-methyljuglone, [6]-gingerol, anacardic acid, baicalin, vitexin, and malabaricone A and B have the potential to be developed as antibacterial leads.Conclusions Angiosperms from Asia and the Pacific provide a rich source of natural products with the potential to be developed as leads for treating bacterial infections. |
| format | Article |
| id | doaj-art-638843fdcd1d4d7093fba4195265ce41 |
| institution | OA Journals |
| issn | 1388-0209 1744-5116 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Pharmaceutical Biology |
| spelling | doaj-art-638843fdcd1d4d7093fba4195265ce412025-08-20T02:30:35ZengTaylor & Francis GroupPharmaceutical Biology1388-02091744-51162024-12-0162171376610.1080/13880209.2024.2407530Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the lightMazdida Sulaiman0Layane Ebehairy1Veeranoot Nissapatorn2Mohammed Rahmatullah3Jhonnel Villegas4Helina Jean Dupa5Ricksterlie C. Verzosa6Karma G. Dolma7Muhamad Shabaz8Scholastica Lanting9Nor Azizun Rusdi10Nor Hayati Abdullah11Mohammed Khaled Bin Break12Teng Jin Khoo13Wei Wang14Christophe Wiart15Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, MalaysiaDepartment of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, MalaysiaSchool of Allied Health Sciences, Walailak University, Nakhon Si Thammarat, ThailandDepartment of Biotechnology, University of Development Alternative, Dhaka, BangladeshFaculty of Education and Teacher Training, Davao Oriental State University, Mati, PhilippinesFaculty of Education and Teacher Training, Davao Oriental State University, Mati, PhilippinesFaculty of Agriculture and Life Science, Davao Oriental State University, Mati, PhilippinesDepartment of Microbiology, Sikkim Manipal University, Gangtok, IndiaInstitute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Kota Kinabalu, MalaysiaInstitute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Kota Kinabalu, MalaysiaInstitute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Kota Kinabalu, MalaysiaNatural Product Division, Forest Research Institute of Malaysia, Kepong, MalaysiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Ha’il, Ha’il, Saudi ArabiaSchool of Pharmacy, University of Nottingham Malaysia, Semenyih, MalaysiaSchool of Pharmacy, Hunan University of Chinese Medicine, Changsha, ChinaInstitute for Tropical Biology and Conservation, Universiti Malaysia Sabah, Kota Kinabalu, MalaysiaContext The emergence of pan-resistant bacteria requires the development of new antibiotics and antibiotic potentiators.Objective This review identifies antibacterial phenolic compounds that have been identified in Asian and Pacific Angiosperms from 1945 to 2023 and analyzes their strengths and spectra of activity, distributions, molecular masses, solubilities, modes of action, structures-activities, as well as their synergistic effects with antibiotics, toxicities, and clinical potential.Methods All data in this review was compiled from Google Scholar, PubMed, Science Direct, Web of Science, and library search; other sources were excluded. We used the following combination of keywords: ‘Phenolic compound’, ‘Plants’, and ‘Antibacterial’. This produced 736 results. Each result was examined and articles that did not contain information relevant to the topic or coming from non-peer-reviewed journals were excluded. Each of the remaining 467 selected articles was read critically for the information that it contained.Results Out of ∼350 antibacterial phenolic compounds identified, 44 were very strongly active, mainly targeting the cytoplasmic membrane of Gram-positive bacteria, and with a molecular mass between 200 and 400 g/mol. 2-Methoxy-7-methyljuglone, [6]-gingerol, anacardic acid, baicalin, vitexin, and malabaricone A and B have the potential to be developed as antibacterial leads.Conclusions Angiosperms from Asia and the Pacific provide a rich source of natural products with the potential to be developed as leads for treating bacterial infections.https://www.tandfonline.com/doi/10.1080/13880209.2024.2407530AngiospermsantibioticsAsia-Pacificinflammationsuperbugs |
| spellingShingle | Mazdida Sulaiman Layane Ebehairy Veeranoot Nissapatorn Mohammed Rahmatullah Jhonnel Villegas Helina Jean Dupa Ricksterlie C. Verzosa Karma G. Dolma Muhamad Shabaz Scholastica Lanting Nor Azizun Rusdi Nor Hayati Abdullah Mohammed Khaled Bin Break Teng Jin Khoo Wei Wang Christophe Wiart Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light Pharmaceutical Biology Angiosperms antibiotics Asia-Pacific inflammation superbugs |
| title | Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light |
| title_full | Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light |
| title_fullStr | Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light |
| title_full_unstemmed | Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light |
| title_short | Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light |
| title_sort | antibacterial phenolic compounds from the flowering plants of asia and the pacific coming to the light |
| topic | Angiosperms antibiotics Asia-Pacific inflammation superbugs |
| url | https://www.tandfonline.com/doi/10.1080/13880209.2024.2407530 |
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