Misidentification of Scedosporium boydii Infection as Aspergillosis in a Patient with Chronic Renal Failure
Aspergillosis is a commonly diagnosed fungal infection. Histopathologic examination alone can have diagnostic pitfalls due to the overlapping of fungal morphology. We report a case of Scedosporium boydii infection initially misdiagnosed as aspergillosis. The patient presented to the hospital with sh...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2020/9727513 |
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| author | Yuying Jiang Amira F Gohara Robert E. Mrak Kenneth L. Muldrew |
| author_facet | Yuying Jiang Amira F Gohara Robert E. Mrak Kenneth L. Muldrew |
| author_sort | Yuying Jiang |
| collection | DOAJ |
| description | Aspergillosis is a commonly diagnosed fungal infection. Histopathologic examination alone can have diagnostic pitfalls due to the overlapping of fungal morphology. We report a case of Scedosporium boydii infection initially misdiagnosed as aspergillosis. The patient presented to the hospital with shortness of breath and chest and abdominal pain. Laboratory tests revealed leukocytosis and elevated serum liver enzymes, myoglobin and lipase. He died of hypotensive shock and brain abscesses despite antibiotic treatment. Autopsy revealed invasive fungal infection in the heart, thyroid, and brain with presence of 45-degree angled, branching hyphae. The initial diagnosis of aspergillosis was made; however, further molecular studies identified the organism as S. boydii. This report reveals the potential pitfalls of morphologic diagnosis alone; and the necessity of other testing modalities to render an accurate diagnosis which is crucial for appropriate. |
| format | Article |
| id | doaj-art-63761e8cf6fa494abe831fa38e71e077 |
| institution | OA Journals |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-63761e8cf6fa494abe831fa38e71e0772025-08-20T02:35:13ZengWileyCase Reports in Infectious Diseases2090-66252090-66332020-01-01202010.1155/2020/97275139727513Misidentification of Scedosporium boydii Infection as Aspergillosis in a Patient with Chronic Renal FailureYuying Jiang0Amira F Gohara1Robert E. Mrak2Kenneth L. Muldrew3Department of Pathology, University of Toledo Medical Center, Toledo, OH 43614, USADepartment of Pathology, University of Toledo Medical Center, Toledo, OH 43614, USADepartment of Pathology, University of Toledo Medical Center, Toledo, OH 43614, USADepartment of Pathology, University of Toledo Medical Center, Toledo, OH 43614, USAAspergillosis is a commonly diagnosed fungal infection. Histopathologic examination alone can have diagnostic pitfalls due to the overlapping of fungal morphology. We report a case of Scedosporium boydii infection initially misdiagnosed as aspergillosis. The patient presented to the hospital with shortness of breath and chest and abdominal pain. Laboratory tests revealed leukocytosis and elevated serum liver enzymes, myoglobin and lipase. He died of hypotensive shock and brain abscesses despite antibiotic treatment. Autopsy revealed invasive fungal infection in the heart, thyroid, and brain with presence of 45-degree angled, branching hyphae. The initial diagnosis of aspergillosis was made; however, further molecular studies identified the organism as S. boydii. This report reveals the potential pitfalls of morphologic diagnosis alone; and the necessity of other testing modalities to render an accurate diagnosis which is crucial for appropriate.http://dx.doi.org/10.1155/2020/9727513 |
| spellingShingle | Yuying Jiang Amira F Gohara Robert E. Mrak Kenneth L. Muldrew Misidentification of Scedosporium boydii Infection as Aspergillosis in a Patient with Chronic Renal Failure Case Reports in Infectious Diseases |
| title | Misidentification of Scedosporium boydii Infection as Aspergillosis in a Patient with Chronic Renal Failure |
| title_full | Misidentification of Scedosporium boydii Infection as Aspergillosis in a Patient with Chronic Renal Failure |
| title_fullStr | Misidentification of Scedosporium boydii Infection as Aspergillosis in a Patient with Chronic Renal Failure |
| title_full_unstemmed | Misidentification of Scedosporium boydii Infection as Aspergillosis in a Patient with Chronic Renal Failure |
| title_short | Misidentification of Scedosporium boydii Infection as Aspergillosis in a Patient with Chronic Renal Failure |
| title_sort | misidentification of scedosporium boydii infection as aspergillosis in a patient with chronic renal failure |
| url | http://dx.doi.org/10.1155/2020/9727513 |
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